Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/1/19 |
| _version_ | 1827698357508767744 |
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| author | Lexin Long Ruojun Wang Ho Yin Chiang Wei Ding Yong-Xin Li Feng Chen Pei-Yuan Qian |
| author_facet | Lexin Long Ruojun Wang Ho Yin Chiang Wei Ding Yong-Xin Li Feng Chen Pei-Yuan Qian |
| author_sort | Lexin Long |
| collection | DOAJ |
| description | Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a screening program of antibiofilm compounds against marine biofilms, we discovered the potent biofilm inhibitory activity of elasnin. Elasnin effectively inhibited the biofilm formation of seven strains of bacteria isolated from marine biofilms. With high productivity, elasnin-based coatings were prepared in an easy and cost-effective way, which exhibited great performance in inhibiting the formation of multi-species biofilms and the attachment of large biofouling organisms in the marine environment. The 16S amplicon analysis and anti-larvae assay revealed that elasnin could prevent biofouling by the indirect impact of changed microbial composition of biofilms and direct inhibitory effect on larval settlement with low toxic effects. These findings indicated the potential application of elasnin in biofilm and biofouling control in the marine environment. |
| first_indexed | 2024-03-10T13:28:15Z |
| format | Article |
| id | doaj.art-a194e0f6bcc84db3bf281ea1931aa5b8 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T13:28:15Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a194e0f6bcc84db3bf281ea1931aa5b82023-11-21T08:38:14ZengMDPI AGMarine Drugs1660-33972021-01-011911910.3390/md19010019Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling CoatingsLexin Long0Ruojun Wang1Ho Yin Chiang2Wei Ding3Yong-Xin Li4Feng Chen5Pei-Yuan Qian6SZU-HKUST Joint PhD Program in Marine Environmental Science, Shenzhen University, Shenzhen 518000, ChinaDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, ChinaDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, ChinaColleague of Marine Life Science, Ocean University of China, 5 Yushan Road, Qingdao 266100, ChinaDepartment of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong 999077, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518060, ChinaDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, ChinaBiofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a screening program of antibiofilm compounds against marine biofilms, we discovered the potent biofilm inhibitory activity of elasnin. Elasnin effectively inhibited the biofilm formation of seven strains of bacteria isolated from marine biofilms. With high productivity, elasnin-based coatings were prepared in an easy and cost-effective way, which exhibited great performance in inhibiting the formation of multi-species biofilms and the attachment of large biofouling organisms in the marine environment. The 16S amplicon analysis and anti-larvae assay revealed that elasnin could prevent biofouling by the indirect impact of changed microbial composition of biofilms and direct inhibitory effect on larval settlement with low toxic effects. These findings indicated the potential application of elasnin in biofilm and biofouling control in the marine environment.https://www.mdpi.com/1660-3397/19/1/19elasninbiofilmsmarinebiofoulingnatural products |
| spellingShingle | Lexin Long Ruojun Wang Ho Yin Chiang Wei Ding Yong-Xin Li Feng Chen Pei-Yuan Qian Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings Marine Drugs elasnin biofilms marine biofouling natural products |
| title | Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings |
| title_full | Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings |
| title_fullStr | Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings |
| title_full_unstemmed | Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings |
| title_short | Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings |
| title_sort | discovery of antibiofilm activity of elasnin against marine biofilms and its application in the marine antifouling coatings |
| topic | elasnin biofilms marine biofouling natural products |
| url | https://www.mdpi.com/1660-3397/19/1/19 |
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