Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease
Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/9937 |
| _version_ | 1797594368700317696 |
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| author | Kristina A. Dvornikova Olga N. Platonova Elena Y. Bystrova |
| author_facet | Kristina A. Dvornikova Olga N. Platonova Elena Y. Bystrova |
| author_sort | Kristina A. Dvornikova |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches. |
| first_indexed | 2024-03-11T02:22:43Z |
| format | Article |
| id | doaj.art-a1951e24058b4d1a9e29c72e5f8d1e98 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:22:43Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a1951e24058b4d1a9e29c72e5f8d1e982023-11-18T10:46:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-012412993710.3390/ijms24129937Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and DiseaseKristina A. Dvornikova0Olga N. Platonova1Elena Y. Bystrova2I.P. Pavlov Institute of Physiology RAS, St. Petersburg 199034, RussiaI.P. Pavlov Institute of Physiology RAS, St. Petersburg 199034, RussiaI.P. Pavlov Institute of Physiology RAS, St. Petersburg 199034, RussiaInflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions. Given the high immunomodulatory activity of histamine and the complex immune-mediated nature of inflammatory bowel disease, the role of histamine and its receptors in the gut may be significant. This paper has been prepared to provide a schematic of the most important and possible molecular signaling pathways related to histamine and its receptors and to assess their relevance for the development of therapeutic approaches.https://www.mdpi.com/1422-0067/24/12/9937histaminehistamine receptorsHDCHNMTDAOintestine |
| spellingShingle | Kristina A. Dvornikova Olga N. Platonova Elena Y. Bystrova Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease International Journal of Molecular Sciences histamine histamine receptors HDC HNMT DAO intestine |
| title | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
| title_full | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
| title_fullStr | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
| title_full_unstemmed | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
| title_short | Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease |
| title_sort | inflammatory bowel disease crosstalk between histamine immunity and disease |
| topic | histamine histamine receptors HDC HNMT DAO intestine |
| url | https://www.mdpi.com/1422-0067/24/12/9937 |
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