Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2021-08-01
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| Series: | ACS Bio & Med Chem Au |
| Online Access: | https://doi.org/10.1021/acsbiomedchemau.1c00024 |
| _version_ | 1818323893571551232 |
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| author | Lisa Barbaro Alice L. Rodriguez Ashlyn N. Blevins Jonathan W. Dickerson Natasha Billard Olivier Boutaud Jerri L. Rook Colleen M. Niswender P.Jeffrey Conn Darren W. Engers Craig W. Lindsley |
| author_facet | Lisa Barbaro Alice L. Rodriguez Ashlyn N. Blevins Jonathan W. Dickerson Natasha Billard Olivier Boutaud Jerri L. Rook Colleen M. Niswender P.Jeffrey Conn Darren W. Engers Craig W. Lindsley |
| author_sort | Lisa Barbaro |
| collection | DOAJ |
| first_indexed | 2024-12-13T11:19:56Z |
| format | Article |
| id | doaj.art-a1962d9086d84ecabe40eff8d58cb02f |
| institution | Directory Open Access Journal |
| issn | 2694-2437 |
| language | English |
| last_indexed | 2024-12-13T11:19:56Z |
| publishDate | 2021-08-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Bio & Med Chem Au |
| spelling | doaj.art-a1962d9086d84ecabe40eff8d58cb02f2022-12-21T23:48:31ZengAmerican Chemical SocietyACS Bio & Med Chem Au2694-24372021-08-0111213010.1021/acsbiomedchemau.1c00024Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM ChemotypeLisa Barbaro0Alice L. Rodriguez1Ashlyn N. Blevins2Jonathan W. Dickerson3Natasha Billard4Olivier Boutaud5Jerri L. Rook6Colleen M. Niswender7P.Jeffrey Conn8Darren W. Engers9Craig W. Lindsley10†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United States†Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee, United Stateshttps://doi.org/10.1021/acsbiomedchemau.1c00024 |
| spellingShingle | Lisa Barbaro Alice L. Rodriguez Ashlyn N. Blevins Jonathan W. Dickerson Natasha Billard Olivier Boutaud Jerri L. Rook Colleen M. Niswender P.Jeffrey Conn Darren W. Engers Craig W. Lindsley Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype ACS Bio & Med Chem Au |
| title | Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype |
| title_full | Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype |
| title_fullStr | Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype |
| title_full_unstemmed | Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype |
| title_short | Discovery of “Molecular Switches” within a Series of mGlu5 Allosteric Ligands Driven by a “Magic Methyl” Effect Affording Both PAMs and NAMs with In Vivo Activity, Derived from an M1 PAM Chemotype |
| title_sort | discovery of molecular switches within a series of mglu5 allosteric ligands driven by a magic methyl effect affording both pams and nams with in vivo activity derived from an m1 pam chemotype |
| url | https://doi.org/10.1021/acsbiomedchemau.1c00024 |
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