Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern
The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study o...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/9/1918 |
| _version_ | 1797576419110289408 |
|---|---|
| author | Ana Medel-Martinez Cristina Paules María Peran Pilar Calvo Sara Ruiz-Martinez María Ormazabal Cundin Alberto Cebollada-Solanas Mark Strunk Jon Schoorlemmer Daniel Oros Marta Fabre |
| author_facet | Ana Medel-Martinez Cristina Paules María Peran Pilar Calvo Sara Ruiz-Martinez María Ormazabal Cundin Alberto Cebollada-Solanas Mark Strunk Jon Schoorlemmer Daniel Oros Marta Fabre |
| author_sort | Ana Medel-Martinez |
| collection | DOAJ |
| description | The original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study of SARS-CoV-2-positive pregnant women between March 2020 and March 2022. The population was divided into pregnancies affected by COVID-19 disease during 2020 (Pre-VOC group) and pregnancies affected after December 2020 by SARS-CoV-2 variants of concern (VOC group). The presence of virus was assessed by RT-PCR, and the viral variant was determined by whole genome sequencing. A total of 104 placentas were examined, among which 54 cases belonged to the Pre-VOC group and 50 cases belonged to the VOC group. Sixteen positive placental RT-PCR tests for SARS-CoV-2 were reported. The NGS analysis confirmed the SARS-CoV-2 lineage in placenta tissue. All samples corresponded to the Pre-VOC group, whereas no placental presence of SARS-CoV-2 was detected in the VOC group (16, 29.6% vs. 0, 0.0% <i>p</i> = 0.000). Preterm birth (9, 16.7% vs. 2, 4%; <i>p</i> = 0.036) and hypertensive disorders of pregnancy (14, 25.9% vs. 3, 6%; <i>p</i> = 0.003) were more frequent in the Pre-VOC group than in the VOC group. Finally, the VOC group was composed of 23 unvaccinated and 27 vaccinated pregnant women; no differences were observed in the sub-analysis focused on vaccination status. In summary, SARS-CoV-2-positive placentas were observed only in pregnancies infected by SARS-CoV-2 wildtype. Thus, placental SARS-CoV-2 presence could be influenced by SARS-CoV-2 variants, infection timing, or vaccination status. According to our data, the current risk of SARS-CoV-2 placental infection after maternal COVID disease during pregnancy should be updated. |
| first_indexed | 2024-03-10T21:51:43Z |
| format | Article |
| id | doaj.art-a1967159ec3d4e1d92b28b21db0afda2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T21:51:43Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a1967159ec3d4e1d92b28b21db0afda22023-11-19T13:23:33ZengMDPI AGViruses1999-49152023-09-01159191810.3390/v15091918Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of ConcernAna Medel-Martinez0Cristina Paules1María Peran2Pilar Calvo3Sara Ruiz-Martinez4María Ormazabal Cundin5Alberto Cebollada-Solanas6Mark Strunk7Jon Schoorlemmer8Daniel Oros9Marta Fabre10Instituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, SpainInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, SpainInstituto Aragonés de Ciencias de la Salud (IACS), Centro de Investigación Biomédica de Aragón (CIBA), 50009 Zaragoza, SpainPlacental Pathophysiology & Fetal Programming Research Group, B46_20R & GIIS-028 del IISA, 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainInstituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, SpainThe original SARS-CoV-2 lineages have been replaced by successive variants of concern (VOCs) over time. The aim of this study was to perform an assessment of the placental infection by SARS-CoV-2 according to the predominant variant at the moment of COVID-19 diagnosis. This was a prospective study of SARS-CoV-2-positive pregnant women between March 2020 and March 2022. The population was divided into pregnancies affected by COVID-19 disease during 2020 (Pre-VOC group) and pregnancies affected after December 2020 by SARS-CoV-2 variants of concern (VOC group). The presence of virus was assessed by RT-PCR, and the viral variant was determined by whole genome sequencing. A total of 104 placentas were examined, among which 54 cases belonged to the Pre-VOC group and 50 cases belonged to the VOC group. Sixteen positive placental RT-PCR tests for SARS-CoV-2 were reported. The NGS analysis confirmed the SARS-CoV-2 lineage in placenta tissue. All samples corresponded to the Pre-VOC group, whereas no placental presence of SARS-CoV-2 was detected in the VOC group (16, 29.6% vs. 0, 0.0% <i>p</i> = 0.000). Preterm birth (9, 16.7% vs. 2, 4%; <i>p</i> = 0.036) and hypertensive disorders of pregnancy (14, 25.9% vs. 3, 6%; <i>p</i> = 0.003) were more frequent in the Pre-VOC group than in the VOC group. Finally, the VOC group was composed of 23 unvaccinated and 27 vaccinated pregnant women; no differences were observed in the sub-analysis focused on vaccination status. In summary, SARS-CoV-2-positive placentas were observed only in pregnancies infected by SARS-CoV-2 wildtype. Thus, placental SARS-CoV-2 presence could be influenced by SARS-CoV-2 variants, infection timing, or vaccination status. According to our data, the current risk of SARS-CoV-2 placental infection after maternal COVID disease during pregnancy should be updated.https://www.mdpi.com/1999-4915/15/9/1918SARS-CoV-2SARS-CoV-2 variants of concernpregnancywaves of COVID-19 |
| spellingShingle | Ana Medel-Martinez Cristina Paules María Peran Pilar Calvo Sara Ruiz-Martinez María Ormazabal Cundin Alberto Cebollada-Solanas Mark Strunk Jon Schoorlemmer Daniel Oros Marta Fabre Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern Viruses SARS-CoV-2 SARS-CoV-2 variants of concern pregnancy waves of COVID-19 |
| title | Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern |
| title_full | Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern |
| title_fullStr | Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern |
| title_full_unstemmed | Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern |
| title_short | Placental Infection Associated with SARS-CoV-2 Wildtype Variant and Variants of Concern |
| title_sort | placental infection associated with sars cov 2 wildtype variant and variants of concern |
| topic | SARS-CoV-2 SARS-CoV-2 variants of concern pregnancy waves of COVID-19 |
| url | https://www.mdpi.com/1999-4915/15/9/1918 |
| work_keys_str_mv | AT anamedelmartinez placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT cristinapaules placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT mariaperan placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT pilarcalvo placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT sararuizmartinez placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT mariaormazabalcundin placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT albertocebolladasolanas placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT markstrunk placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT jonschoorlemmer placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT danieloros placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern AT martafabre placentalinfectionassociatedwithsarscov2wildtypevariantandvariantsofconcern |