Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice
Terminalia catappa L. (TC) trees are grown in many parts of the world including Vietnam, their seeds have high lipids content used as feed, and the yield of Terminalia catappa L. seed oil (TCO) is high. A survey on Mus musculus L mice was conducted, in addition to the diet they were also given TCO d...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Journal of Agriculture and Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154323000947 |
| _version_ | 1797823100511846400 |
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| author | Le Hong Nguy Le Bao HA. Tran Thi Anh Dao Dong |
| author_facet | Le Hong Nguy Le Bao HA. Tran Thi Anh Dao Dong |
| author_sort | Le Hong Nguy |
| collection | DOAJ |
| description | Terminalia catappa L. (TC) trees are grown in many parts of the world including Vietnam, their seeds have high lipids content used as feed, and the yield of Terminalia catappa L. seed oil (TCO) is high. A survey on Mus musculus L mice was conducted, in addition to the diet they were also given TCO daily to evaluate its safety and effects. Results after 72 h of use with the highest oral dose of 21780 mg/kg of mice, all instinctive behaviors of mice were normal, the survival rate was 100%, when increasing the oral dose to the weight of mice, there was a tendency of slight downward tend. Continuously given daily dose of 5445 mg/kg of mice for 14 and 28 days, no abnormalities affecting instinctive behaviors were detected, the weight of mice fluctuated but not much, Mouse death rate is 0%. Analysis results of blood physiological parameters including RBC (Red Blood Cell), HGB (Hemoglobin), HCT (Hematocrit), WBC (White Blood Cell), LYM (Lymphocyte), NEU (Neutrophil), PLT (Platelet Count) values are within the standard limits of healthy mice. Some other findings when prolonging the intake of TCO, the mouse coat was thick, soft, and smooth compared to the short time of 72-h use, the concentration of ALT (alanine aminotransferase), AST (aspartate aminotransferase) decreased to the standard of healthy mice that can regulate liver enzymes to reduce liver damage. Creatinine levels related to kidney function are low, but when observing the microscopic liver and kidney tissue, no lesions or abnormalities are detected. |
| first_indexed | 2024-03-13T10:19:02Z |
| format | Article |
| id | doaj.art-a19b5e086b34402c84aa2233829b1b1f |
| institution | Directory Open Access Journal |
| issn | 2666-1543 |
| language | English |
| last_indexed | 2024-03-13T10:19:02Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj.art-a19b5e086b34402c84aa2233829b1b1f2023-05-21T04:35:47ZengElsevierJournal of Agriculture and Food Research2666-15432023-06-0112100587Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L miceLe Hong Nguy0Le Bao HA. Tran1Thi Anh Dao Dong2Department of Food Technology, Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Viet Nam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Viet Nam; Corresponding author. Vietnam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Viet Nam.Vietnam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Viet Nam; Department of Physiology and Animal Biotechnology, Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City, Viet NamDepartment of Food Technology, Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Viet Nam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Viet Nam; Corresponding author. Vietnam National University Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Viet Nam.Terminalia catappa L. (TC) trees are grown in many parts of the world including Vietnam, their seeds have high lipids content used as feed, and the yield of Terminalia catappa L. seed oil (TCO) is high. A survey on Mus musculus L mice was conducted, in addition to the diet they were also given TCO daily to evaluate its safety and effects. Results after 72 h of use with the highest oral dose of 21780 mg/kg of mice, all instinctive behaviors of mice were normal, the survival rate was 100%, when increasing the oral dose to the weight of mice, there was a tendency of slight downward tend. Continuously given daily dose of 5445 mg/kg of mice for 14 and 28 days, no abnormalities affecting instinctive behaviors were detected, the weight of mice fluctuated but not much, Mouse death rate is 0%. Analysis results of blood physiological parameters including RBC (Red Blood Cell), HGB (Hemoglobin), HCT (Hematocrit), WBC (White Blood Cell), LYM (Lymphocyte), NEU (Neutrophil), PLT (Platelet Count) values are within the standard limits of healthy mice. Some other findings when prolonging the intake of TCO, the mouse coat was thick, soft, and smooth compared to the short time of 72-h use, the concentration of ALT (alanine aminotransferase), AST (aspartate aminotransferase) decreased to the standard of healthy mice that can regulate liver enzymes to reduce liver damage. Creatinine levels related to kidney function are low, but when observing the microscopic liver and kidney tissue, no lesions or abnormalities are detected.http://www.sciencedirect.com/science/article/pii/S2666154323000947Terminalia catappa L. seed oil (TCO)Mus musculus LBlood physiological parameters |
| spellingShingle | Le Hong Nguy Le Bao HA. Tran Thi Anh Dao Dong Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice Journal of Agriculture and Food Research Terminalia catappa L. seed oil (TCO) Mus musculus L Blood physiological parameters |
| title | Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice |
| title_full | Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice |
| title_fullStr | Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice |
| title_full_unstemmed | Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice |
| title_short | Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice |
| title_sort | effects of edible terminalia catappa l seed oil on physiological parameters of mus musculus l mice |
| topic | Terminalia catappa L. seed oil (TCO) Mus musculus L Blood physiological parameters |
| url | http://www.sciencedirect.com/science/article/pii/S2666154323000947 |
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