Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells
Amphibole asbestos is related to multiple diseases, mainly those targeting the lungs. Asbestos-related malignancies can also be caused by non-regulated asbestiform minerals and some elongated mineral particles (EMPs). In particular, the role of nano- and micro-sized EMPs internalized by lung epithel...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Minerals |
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| Online Access: | https://www.mdpi.com/2075-163X/14/1/101 |
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| author | Ruggero Vigliaturo Maja Jamnik Goran Dražić Marjetka Podobnik Magda Tušek Žnidarič Giancarlo Della Ventura Günther J. Redhammer Nada Žnidaršič Simon Caserman Reto Gieré |
| author_facet | Ruggero Vigliaturo Maja Jamnik Goran Dražić Marjetka Podobnik Magda Tušek Žnidarič Giancarlo Della Ventura Günther J. Redhammer Nada Žnidaršič Simon Caserman Reto Gieré |
| author_sort | Ruggero Vigliaturo |
| collection | DOAJ |
| description | Amphibole asbestos is related to multiple diseases, mainly those targeting the lungs. Asbestos-related malignancies can also be caused by non-regulated asbestiform minerals and some elongated mineral particles (EMPs). In particular, the role of nano- and micro-sized EMPs internalized by lung epithelial cells must be clarified. This is of major importance when considering that EMPs to which humans are exposed are likely a highly heterogeneous mix of different mineral types, shapes, and sizes. Here, we document that particles smaller than 4.54 µm in length and smaller than 0.89 µm in width (e.g., particles that do not fit the regulatory categories to be identified as asbestos) are easily internalized because of their specific dimensions, surface charge, and shape (mostly dictated by the aspect ratio <i>L/w</i>). Once internalized, these particles can be found in proximity to the cell nucleus, in vesicles, and in the cytoplasm. Examining the localization of particles in cells provides important information, which helps in determining the physicochemical environment found inside the biological compartment, thus allowing for a better comprehension of the mineralogical transformation that might happen after internalization by cells. |
| first_indexed | 2024-03-08T10:39:33Z |
| format | Article |
| id | doaj.art-a19b8142f62c43c3a2eb7312edbb3404 |
| institution | Directory Open Access Journal |
| issn | 2075-163X |
| language | English |
| last_indexed | 2024-03-08T10:39:33Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Minerals |
| spelling | doaj.art-a19b8142f62c43c3a2eb7312edbb34042024-01-26T17:53:01ZengMDPI AGMinerals2075-163X2024-01-0114110110.3390/min14010101Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial CellsRuggero Vigliaturo0Maja Jamnik1Goran Dražić2Marjetka Podobnik3Magda Tušek Žnidarič4Giancarlo Della Ventura5Günther J. Redhammer6Nada Žnidaršič7Simon Caserman8Reto Gieré9Department of Earth Sciences, University of Torino, 10125 Torino, ItalyDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, SloveniaDepartment of Materials Chemistry, National Institute of Chemistry, 1000 Ljubljana, SloveniaDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, SloveniaDepartment of Biotechnology and System Biology, National Institute of Biology, 1000 Ljubljana, SloveniaDepartment of Sciences, University of Roma Tre, 00146 Roma, ItalyDepartment of Materials Science & Physics, University of Salzburg, 5020 Salzburg, AustriaDepartment of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment of Molecular Biology and Nanobiotechnology, National Institute of Chemistry, 1000 Ljubljana, SloveniaDepartment of Earth and Environmental Science, University of Pennsylvania, Philadelphia, PA 19104, USAAmphibole asbestos is related to multiple diseases, mainly those targeting the lungs. Asbestos-related malignancies can also be caused by non-regulated asbestiform minerals and some elongated mineral particles (EMPs). In particular, the role of nano- and micro-sized EMPs internalized by lung epithelial cells must be clarified. This is of major importance when considering that EMPs to which humans are exposed are likely a highly heterogeneous mix of different mineral types, shapes, and sizes. Here, we document that particles smaller than 4.54 µm in length and smaller than 0.89 µm in width (e.g., particles that do not fit the regulatory categories to be identified as asbestos) are easily internalized because of their specific dimensions, surface charge, and shape (mostly dictated by the aspect ratio <i>L/w</i>). Once internalized, these particles can be found in proximity to the cell nucleus, in vesicles, and in the cytoplasm. Examining the localization of particles in cells provides important information, which helps in determining the physicochemical environment found inside the biological compartment, thus allowing for a better comprehension of the mineralogical transformation that might happen after internalization by cells.https://www.mdpi.com/2075-163X/14/1/101asbestos localizationnanoparticlesmedical mineralogy |
| spellingShingle | Ruggero Vigliaturo Maja Jamnik Goran Dražić Marjetka Podobnik Magda Tušek Žnidarič Giancarlo Della Ventura Günther J. Redhammer Nada Žnidaršič Simon Caserman Reto Gieré Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells Minerals asbestos localization nanoparticles medical mineralogy |
| title | Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells |
| title_full | Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells |
| title_fullStr | Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells |
| title_full_unstemmed | Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells |
| title_short | Localization and Dimensional Range of Amphibole Particles Retrieved from Human Alveolar Epithelial Cells |
| title_sort | localization and dimensional range of amphibole particles retrieved from human alveolar epithelial cells |
| topic | asbestos localization nanoparticles medical mineralogy |
| url | https://www.mdpi.com/2075-163X/14/1/101 |
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