Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome
The gut microbiota modulates overall metabolism, the immune system and brain development of the host. The majority of mammalian gut microbiota consists of bacteria. Among various model animals, the mouse has been most widely used in pre-clinical biological experiments. The significant compositional...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/7/11/480 |
| _version_ | 1819136231699644416 |
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| author | Junwon Yang Jonghyun Park Sein Park Inwoo Baek Jongsik Chun |
| author_facet | Junwon Yang Jonghyun Park Sein Park Inwoo Baek Jongsik Chun |
| author_sort | Junwon Yang |
| collection | DOAJ |
| description | The gut microbiota modulates overall metabolism, the immune system and brain development of the host. The majority of mammalian gut microbiota consists of bacteria. Among various model animals, the mouse has been most widely used in pre-clinical biological experiments. The significant compositional differences in taxonomic profiles among different mouse strains due to gastrointestinal locations, genotypes and vendors have been well documented. However, details of such variations are yet to be elucidated. This study compiled and analyzed 16S rRNA gene-based taxonomic profiles of 554 healthy mouse samples from 14 different projects to construct a comprehensive database of the microbiome of a healthy mouse gastrointestinal tract. The database, named Murine Microbiome Database, should provide researchers with useful taxonomic information and better biological insight about how each taxon, such as genus and species, is associated with locations in the gastrointestinal tract, genotypes and vendors. The database is freely accessible over the Internet. |
| first_indexed | 2024-12-22T10:31:42Z |
| format | Article |
| id | doaj.art-a19c4db35a934b1ab65e38309230d1c5 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-22T10:31:42Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a19c4db35a934b1ab65e38309230d1c52022-12-21T18:29:18ZengMDPI AGMicroorganisms2076-26072019-10-0171148010.3390/microorganisms7110480microorganisms7110480Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal MicrobiomeJunwon Yang0Jonghyun Park1Sein Park2Inwoo Baek3Jongsik Chun4Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, KoreaInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, KoreaInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, KoreaInstitute of Molecular Biology & Genetics, Seoul National University, Seoul 08826, KoreaInterdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, KoreaThe gut microbiota modulates overall metabolism, the immune system and brain development of the host. The majority of mammalian gut microbiota consists of bacteria. Among various model animals, the mouse has been most widely used in pre-clinical biological experiments. The significant compositional differences in taxonomic profiles among different mouse strains due to gastrointestinal locations, genotypes and vendors have been well documented. However, details of such variations are yet to be elucidated. This study compiled and analyzed 16S rRNA gene-based taxonomic profiles of 554 healthy mouse samples from 14 different projects to construct a comprehensive database of the microbiome of a healthy mouse gastrointestinal tract. The database, named Murine Microbiome Database, should provide researchers with useful taxonomic information and better biological insight about how each taxon, such as genus and species, is associated with locations in the gastrointestinal tract, genotypes and vendors. The database is freely accessible over the Internet.https://www.mdpi.com/2076-2607/7/11/480databasemetagenomicsmouse gut microbiome |
| spellingShingle | Junwon Yang Jonghyun Park Sein Park Inwoo Baek Jongsik Chun Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome Microorganisms database metagenomics mouse gut microbiome |
| title | Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome |
| title_full | Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome |
| title_fullStr | Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome |
| title_full_unstemmed | Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome |
| title_short | Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome |
| title_sort | introducing murine microbiome database mmdb a curated database with taxonomic profiling of the healthy mouse gastrointestinal microbiome |
| topic | database metagenomics mouse gut microbiome |
| url | https://www.mdpi.com/2076-2607/7/11/480 |
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