Association between systemic immune-inflammation index and insulin resistance and mortality
Abstract The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) and mortality remains uncertain. We aim to explore the potential correlation between systemic immune-inflammation index (SI...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51878-y |
| _version_ | 1797276626820530176 |
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| author | Xiaoqi Deng Dichuan Liu Miao Li Jie He Yufan Fu |
| author_facet | Xiaoqi Deng Dichuan Liu Miao Li Jie He Yufan Fu |
| author_sort | Xiaoqi Deng |
| collection | DOAJ |
| description | Abstract The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) and mortality remains uncertain. We aim to explore the potential correlation between systemic immune-inflammation index (SII) and these factors. We used data from 2011 to 2016 of National Health and Nutrition Examination Survey, and multivariate logistic regression and restricted cubic spline were employed. Subgroup and interaction analysis were conducted to recognize the consistency of the results. The association between SII and mortality was described by survival analysis. 6734 participants were enrolled, of whom 49.3% (3318) exhibited IR and 7.02% experienced mortality. Multivariate logistic regression revealed that individuals in the highest quartile (Q4) of SII had a significantly increased risk of IR compared to those in the lowest quartile (Q1). We then identified a linear association between SII and IR with an inflection point of 407, but may be influenced by gender. Similarly, compared to Q1, people whose SII at Q4 showed a higher all-cause and cardiovascular mortality. It showed a significant association between SII and both all-cause and cardiovascular mortality, but the results need to be interpreted with caution. |
| first_indexed | 2024-03-07T15:30:56Z |
| format | Article |
| id | doaj.art-a19f73e9666b48408b894b7a99a183ff |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:30:56Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a19f73e9666b48408b894b7a99a183ff2024-03-05T16:25:28ZengNature PortfolioScientific Reports2045-23222024-01-0114111210.1038/s41598-024-51878-yAssociation between systemic immune-inflammation index and insulin resistance and mortalityXiaoqi Deng0Dichuan Liu1Miao Li2Jie He3Yufan Fu4Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityNursing Department, Beijing Tiantan HospitalDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Chongqing Medical UniversityAbstract The role of inflammation in disease promotion is significant, yet the precise association between a newly identified inflammatory biomarker and insulin resistance (IR) and mortality remains uncertain. We aim to explore the potential correlation between systemic immune-inflammation index (SII) and these factors. We used data from 2011 to 2016 of National Health and Nutrition Examination Survey, and multivariate logistic regression and restricted cubic spline were employed. Subgroup and interaction analysis were conducted to recognize the consistency of the results. The association between SII and mortality was described by survival analysis. 6734 participants were enrolled, of whom 49.3% (3318) exhibited IR and 7.02% experienced mortality. Multivariate logistic regression revealed that individuals in the highest quartile (Q4) of SII had a significantly increased risk of IR compared to those in the lowest quartile (Q1). We then identified a linear association between SII and IR with an inflection point of 407, but may be influenced by gender. Similarly, compared to Q1, people whose SII at Q4 showed a higher all-cause and cardiovascular mortality. It showed a significant association between SII and both all-cause and cardiovascular mortality, but the results need to be interpreted with caution.https://doi.org/10.1038/s41598-024-51878-y |
| spellingShingle | Xiaoqi Deng Dichuan Liu Miao Li Jie He Yufan Fu Association between systemic immune-inflammation index and insulin resistance and mortality Scientific Reports |
| title | Association between systemic immune-inflammation index and insulin resistance and mortality |
| title_full | Association between systemic immune-inflammation index and insulin resistance and mortality |
| title_fullStr | Association between systemic immune-inflammation index and insulin resistance and mortality |
| title_full_unstemmed | Association between systemic immune-inflammation index and insulin resistance and mortality |
| title_short | Association between systemic immune-inflammation index and insulin resistance and mortality |
| title_sort | association between systemic immune inflammation index and insulin resistance and mortality |
| url | https://doi.org/10.1038/s41598-024-51878-y |
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