Administration of protopine prevents mitophagy and acute lung injury in sepsis

Administration of protopine prevents mitophagy and acute lung injury in sepsis

Introduction: Sepsis is a severe life-threatening infection that induces a series of dysregulated physiologic responses and results in organ dysfunction. Acute lung injury (ALI), the primary cause of respiratory failure brought on by sepsis, does not have a specific therapy. Protopine (PTP) is an al...

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Bibliographic Details
Main Authors: Zhong Xiao, Juan Long, Jie Zhang, Zhimin Qiu, Chen Zhang, Hongbing Liu, Xinyong Liu, Kang Wang, Yahui Tang, Longwang Chen, Zhongqiu Lu, Guangju Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
sepsis
acute lung injury/ALI
protopine/PTP
inflammation
mitophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1104185/full

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