Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review
Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for th...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/18/2774 |
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| author | Yazhou Liu Chunlong Liu Xiaohong Kou Yumeng Wang Yue Yu Ni Zhen Jingyu Jiang Puba Zhaxi Zhaohui Xue |
| author_facet | Yazhou Liu Chunlong Liu Xiaohong Kou Yumeng Wang Yue Yu Ni Zhen Jingyu Jiang Puba Zhaxi Zhaohui Xue |
| author_sort | Yazhou Liu |
| collection | DOAJ |
| description | Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications. |
| first_indexed | 2024-03-10T00:03:28Z |
| format | Article |
| id | doaj.art-a1a1325c9aa34a40b6aa555a25adf18c |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T00:03:28Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-a1a1325c9aa34a40b6aa555a25adf18c2023-11-23T16:12:57ZengMDPI AGFoods2304-81582022-09-011118277410.3390/foods11182774Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A ReviewYazhou Liu0Chunlong Liu1Xiaohong Kou2Yumeng Wang3Yue Yu4Ni Zhen5Jingyu Jiang6Puba Zhaxi7Zhaohui Xue8School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaFood and Drug Inspection and Research Institute of Tibet Autonomous Region, Lhasa 850000, ChinaFood and Drug Inspection and Research Institute of Tibet Autonomous Region, Lhasa 850000, ChinaFood and Drug Inspection and Research Institute of Tibet Autonomous Region, Lhasa 850000, ChinaSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, ChinaHyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients. The current review focuses on the effects of single phytochemicals on hyperlipidemia and its mechanisms. Due to the complexity of the lipid metabolism regulatory network, the synergistic regulation of different metabolic pathways or targets may be more effective than single pathways or targets in the treatment of hyperlipidemia. This review summarizes for the first time the synergistic hypolipidemic effects of different combinations of phytochemicals such as combinations of the same category of phytochemicals and combinations of different categories of phytochemicals. In addition, based on the different metabolic pathways or targets involved in synergistic effects, the possible mechanisms of synergistic hypolipidemic effects of the phytochemical combination are illustrated in this review. Hence, this review provides clues to boost more phytochemical synergistic hypolipidemic research and provides a theoretical basis for the development of phytochemicals with synergistic effects on hyperlipidemia and its complications.https://www.mdpi.com/2304-8158/11/18/2774synergistic hypolipidemic effectphytochemicalsaction mechanismstructure-bioactive relationshipcombinationlipid metabolic pathways |
| spellingShingle | Yazhou Liu Chunlong Liu Xiaohong Kou Yumeng Wang Yue Yu Ni Zhen Jingyu Jiang Puba Zhaxi Zhaohui Xue Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review Foods synergistic hypolipidemic effect phytochemicals action mechanism structure-bioactive relationship combination lipid metabolic pathways |
| title | Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review |
| title_full | Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review |
| title_fullStr | Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review |
| title_full_unstemmed | Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review |
| title_short | Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review |
| title_sort | synergistic hypolipidemic effects and mechanisms of phytochemicals a review |
| topic | synergistic hypolipidemic effect phytochemicals action mechanism structure-bioactive relationship combination lipid metabolic pathways |
| url | https://www.mdpi.com/2304-8158/11/18/2774 |
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