Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT

Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT

Abstract Background Doxorubicin (DOX) has limited chemotherapy application for malignancies due to cardiotoxicity. The pathogenesis of DOX-induced cardiomyopathy (DiCM) is yet to be elucidated. Increasing studies proved that activation of AKT prevented cardiomyocyte apoptosis and cardiac dysfunction...

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Bibliographic Details
Main Authors: Yu Qi, Jianzhou Chen, Junfeng Duan, Lina Kang, Kun Wang, Ziwei Chen, Biao Xu, Rong Gu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Cardiovascular Disorders
Subjects:
Doxorubicin-induced cardiomyopathy
Major vault protein
AKT
Apoptosis
Online Access:https://doi.org/10.1186/s12872-022-02517-9

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