DOCKING OF TYROSINASE CICLOARTANE INHIBITORS
Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity...
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2009-07-01
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| Series: | Vitae |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/vitae/article/view/1937 |
| _version_ | 1818370086126223360 |
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| author | Pablo A. GUTIÉRREZ Benjamín A. ROJANO |
| author_facet | Pablo A. GUTIÉRREZ Benjamín A. ROJANO |
| author_sort | Pablo A. GUTIÉRREZ |
| collection | DOAJ |
| description | Berenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds. However, the mechanism of inhibition of these molecules is not well understood. This paper present the results of a docking study between Berenjenol and its derivatives on tyrosinase enzyme that provides a rational framework for understanding the activity of these compounds. According to this work, Berenjenol acts as a competitive inhibitor of tyrosinase through interactions with Ile42, Met43 Arg55, Trp184, Asn191, His194, Val195, Ala202, Met201 and Thr203. |
| first_indexed | 2024-12-13T23:34:08Z |
| format | Article |
| id | doaj.art-a1a4242e93b748af9e8e6735b0157d5e |
| institution | Directory Open Access Journal |
| issn | 0121-4004 2145-2660 |
| language | English |
| last_indexed | 2024-12-13T23:34:08Z |
| publishDate | 2009-07-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Vitae |
| spelling | doaj.art-a1a4242e93b748af9e8e6735b0157d5e2022-12-21T23:27:21ZengUniversidad de AntioquiaVitae0121-40042145-26602009-07-01162DOCKING OF TYROSINASE CICLOARTANE INHIBITORSPablo A. GUTIÉRREZ0Benjamín A. ROJANO1Grupo de Biotecnología Microbiana, Escuela de Biociencias, Facultad de Ciencias, Universidad Nacional de Colombia Sede Medellín.Grupo de Productos Naturales y de los Alimentos, Laboratorio de Ciencia de los Alimentos, Facultad de Ciencias, Universidad NacionalBerenjenol (21:24-epoxy-24-methyl-cicloartane) isolated from leaves of Oxandra cf. xylopioides (Annonaceae), and its synthetic derivatives Berenjenol-3-acetate and 3-Oxoberenjenol are tyrosinase inhibitors (EC 1.14.18.1). These compounds are triterpenoids type cycloartanes, whose structure-activity relationship has been studied on similar compounds. However, the mechanism of inhibition of these molecules is not well understood. This paper present the results of a docking study between Berenjenol and its derivatives on tyrosinase enzyme that provides a rational framework for understanding the activity of these compounds. According to this work, Berenjenol acts as a competitive inhibitor of tyrosinase through interactions with Ile42, Met43 Arg55, Trp184, Asn191, His194, Val195, Ala202, Met201 and Thr203.https://revistas.udea.edu.co/index.php/vitae/article/view/1937dockingtyrosinasecicloartaneinhibitor. |
| spellingShingle | Pablo A. GUTIÉRREZ Benjamín A. ROJANO DOCKING OF TYROSINASE CICLOARTANE INHIBITORS Vitae docking tyrosinase cicloartane inhibitor. |
| title | DOCKING OF TYROSINASE CICLOARTANE INHIBITORS |
| title_full | DOCKING OF TYROSINASE CICLOARTANE INHIBITORS |
| title_fullStr | DOCKING OF TYROSINASE CICLOARTANE INHIBITORS |
| title_full_unstemmed | DOCKING OF TYROSINASE CICLOARTANE INHIBITORS |
| title_short | DOCKING OF TYROSINASE CICLOARTANE INHIBITORS |
| title_sort | docking of tyrosinase cicloartane inhibitors |
| topic | docking tyrosinase cicloartane inhibitor. |
| url | https://revistas.udea.edu.co/index.php/vitae/article/view/1937 |
| work_keys_str_mv | AT pabloagutierrez dockingoftyrosinasecicloartaneinhibitors AT benjaminarojano dockingoftyrosinasecicloartaneinhibitors |