Visfatin level in children and adolescents with autoimmune thyroiditis
Background: This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables. Methods The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-08-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/2042018817731073 |
| _version_ | 1828409170500517888 |
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| author | Hekma Saad Farghaly Kotb Abbass Metwalley Faisal-Alkhateeb Ahmed Duaa Mohamed Raafat Osama El-Asheer Ahmed Mahmood Ali Ahlam Bahdawy Asmaa Mohamed Zahran |
| author_facet | Hekma Saad Farghaly Kotb Abbass Metwalley Faisal-Alkhateeb Ahmed Duaa Mohamed Raafat Osama El-Asheer Ahmed Mahmood Ali Ahlam Bahdawy Asmaa Mohamed Zahran |
| author_sort | Hekma Saad Farghaly |
| collection | DOAJ |
| description | Background: This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables. Methods The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, insulin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibody (TgAb) were completed, with assessment of visfatin levels. Results: Overt hypothyroidism was diagnosed in 58 cases, while subclinical hypothyroidism was diagnosed in 26 of the studied patients. Total studied cases, overt and subclinical subgroups had significantly higher levels of TSH, HOMA-IR, TPOAb, TgAb and visfatin and significantly lower FT4 level compared with the control. Spearman correlation analysis revealed that visfatin was correlated positively with BMI, homeostasis model assessment (HOMA-IR), TSH and TPOAb, while inversely correlation with FT4. In logistic regression analysis, visfatin was correlated only with TPOAb. Conclusions: This preliminary study provides evidence of significantly higher level of visfatin in children and adolescents with AIT. Visfatin might have a potential role in the pathogenesis of AIT, which needs to be validated by measuring immunological responses in children and adolescents with AIT. |
| first_indexed | 2024-12-10T11:51:55Z |
| format | Article |
| id | doaj.art-a1a6d863853c49f69d6419de940ad809 |
| institution | Directory Open Access Journal |
| issn | 2042-0188 2042-0196 |
| language | English |
| last_indexed | 2024-12-10T11:51:55Z |
| publishDate | 2017-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-a1a6d863853c49f69d6419de940ad8092022-12-22T01:49:55ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01882042-01962017-08-01810.1177/2042018817731073Visfatin level in children and adolescents with autoimmune thyroiditisHekma Saad FarghalyKotb Abbass MetwalleyFaisal-Alkhateeb AhmedDuaa Mohamed RaafatOsama El-AsheerAhmed Mahmood AliAhlam BahdawyAsmaa Mohamed ZahranBackground: This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables. Methods The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, insulin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibody (TgAb) were completed, with assessment of visfatin levels. Results: Overt hypothyroidism was diagnosed in 58 cases, while subclinical hypothyroidism was diagnosed in 26 of the studied patients. Total studied cases, overt and subclinical subgroups had significantly higher levels of TSH, HOMA-IR, TPOAb, TgAb and visfatin and significantly lower FT4 level compared with the control. Spearman correlation analysis revealed that visfatin was correlated positively with BMI, homeostasis model assessment (HOMA-IR), TSH and TPOAb, while inversely correlation with FT4. In logistic regression analysis, visfatin was correlated only with TPOAb. Conclusions: This preliminary study provides evidence of significantly higher level of visfatin in children and adolescents with AIT. Visfatin might have a potential role in the pathogenesis of AIT, which needs to be validated by measuring immunological responses in children and adolescents with AIT.https://doi.org/10.1177/2042018817731073 |
| spellingShingle | Hekma Saad Farghaly Kotb Abbass Metwalley Faisal-Alkhateeb Ahmed Duaa Mohamed Raafat Osama El-Asheer Ahmed Mahmood Ali Ahlam Bahdawy Asmaa Mohamed Zahran Visfatin level in children and adolescents with autoimmune thyroiditis Therapeutic Advances in Endocrinology and Metabolism |
| title | Visfatin level in children and adolescents with autoimmune thyroiditis |
| title_full | Visfatin level in children and adolescents with autoimmune thyroiditis |
| title_fullStr | Visfatin level in children and adolescents with autoimmune thyroiditis |
| title_full_unstemmed | Visfatin level in children and adolescents with autoimmune thyroiditis |
| title_short | Visfatin level in children and adolescents with autoimmune thyroiditis |
| title_sort | visfatin level in children and adolescents with autoimmune thyroiditis |
| url | https://doi.org/10.1177/2042018817731073 |
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