IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS
Abstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/621 |
| _version_ | 1797198035182157824 |
|---|---|
| author | M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova |
| author_facet | M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova |
| author_sort | M. D. Guliamova |
| collection | DOAJ |
| description | Abstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (HSV) infection was characterized by decreased expression of CD3+ and CD4+ lymphocytes, IgG hypoglobulinaemia. Irrespectively of etiology, both groups of the patients exhibited sharp increase in CD16+ cells, as well as suppressed CD25+ receptors for IL-2, increased numbers of activated CD38+ lymphocytes, enhanced expression of late activation markers (CD95+ and HLA-DR+) in both mixed and single-pathogen uveitis. IFN-alpha is detected at low concentrations, or is absent; increased TNF-alpha production was noted in the tears in cases of posterior uveitis.Statistically significant interrelations have been found between expression of HLA-DR+, and CD3+; CD95+ and HLA-DR+; CD95+ lymphocytes and TNFalpha levels in the course of chronic persistence of Herpesviridae in the patients with chronic uveitis. The degree of immunological disturbances correlated with severity of clinical features. |
| first_indexed | 2024-03-08T05:49:58Z |
| format | Article |
| id | doaj.art-a1a899be32b24759bd16f0b0db1d83db |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:27Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a1a899be32b24759bd16f0b0db1d83db2024-04-22T13:07:38ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0175-654355010.15789/1563-0625-2005-5-6-543-550618IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUSM. D. Guliamova0A. P. Rizopulu1H. M. Kamilov2U. S. Faisieva3A. A. Umarova4F. Yu. Garib5T. U. Aripova6Ташкентский Институт усовершенствования врачей МЗ РУзГМУ им. акад. И.П. Павлова, Санкт-ПетербургТашкентский Институт усовершенствования врачей МЗ РУзТашкентский Институт усовершенствования врачей МЗ РУзИнститут иммунологии АН РУз, ТашкентГМУ им. акад. И.П. Павлова, Санкт-ПетербургИнститут иммунологии АН РУз, ТашкентAbstract. The study included patients with chronic uveitis caused by herpes simplex virus (HSV), or mixed HSV/ cytomegalovirus (CMV) infections. Deficiencies in CD3+ and CD4+ T lymphocytes and significant increase of CD8+ lymphocyte subpopulations were found in posterior uveitis. A single-pathogen (HSV) infection was characterized by decreased expression of CD3+ and CD4+ lymphocytes, IgG hypoglobulinaemia. Irrespectively of etiology, both groups of the patients exhibited sharp increase in CD16+ cells, as well as suppressed CD25+ receptors for IL-2, increased numbers of activated CD38+ lymphocytes, enhanced expression of late activation markers (CD95+ and HLA-DR+) in both mixed and single-pathogen uveitis. IFN-alpha is detected at low concentrations, or is absent; increased TNF-alpha production was noted in the tears in cases of posterior uveitis.Statistically significant interrelations have been found between expression of HLA-DR+, and CD3+; CD95+ and HLA-DR+; CD95+ lymphocytes and TNFalpha levels in the course of chronic persistence of Herpesviridae in the patients with chronic uveitis. The degree of immunological disturbances correlated with severity of clinical features.https://www.mimmun.ru/mimmun/article/view/621uveitiscytomegalovirusherpes simplex viruscytokineslymphocytes activation markers |
| spellingShingle | M. D. Guliamova A. P. Rizopulu H. M. Kamilov U. S. Faisieva A. A. Umarova F. Yu. Garib T. U. Aripova IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS Медицинская иммунология uveitis cytomegalovirus herpes simplex virus cytokines lymphocytes activation markers |
| title | IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS |
| title_full | IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS |
| title_fullStr | IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS |
| title_full_unstemmed | IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS |
| title_short | IMMUNOLOGICAL CHARACTERIZATION OF THE PATIENTS WITH CHRONIC UVEITIS CAUSED BY HERPES AND CYTOMEGALOVIRUS |
| title_sort | immunological characterization of the patients with chronic uveitis caused by herpes and cytomegalovirus |
| topic | uveitis cytomegalovirus herpes simplex virus cytokines lymphocytes activation markers |
| url | https://www.mimmun.ru/mimmun/article/view/621 |
| work_keys_str_mv | AT mdguliamova immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT aprizopulu immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT hmkamilov immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT usfaisieva immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT aaumarova immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT fyugarib immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus AT tuaripova immunologicalcharacterizationofthepatientswithchronicuveitiscausedbyherpesandcytomegalovirus |