Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage
Histones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytoso...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-05-01
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| Series: | Frontiers in Genetics |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00091/full |
| _version_ | 1818519654441680896 |
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| author | Kouji eKobiyama Kouji eKobiyama Akira eKawashima Akira eKawashima Nao eJounai Fumihiko eTakeshita Ken J. Ishii Ken J. Ishii Tetsuhide eIto Koichi eSuzuki |
| author_facet | Kouji eKobiyama Kouji eKobiyama Akira eKawashima Akira eKawashima Nao eJounai Fumihiko eTakeshita Ken J. Ishii Ken J. Ishii Tetsuhide eIto Koichi eSuzuki |
| author_sort | Kouji eKobiyama |
| collection | DOAJ |
| description | Histones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytosolic sensor to detect double-stranded DNA (dsDNA) fragments derived from infectious agents or damaged cells to activate innate and acquired immune responses in various cell types. It also physically interacts with interferon (IFN)-β promoter stimulator 1 (IPS-1), an essential adaptor molecule that activates innate immunity, through COOH-terminal importin 9-related adaptor organizing histone H2B and IPS-1 (CIAO), resulting in a distinct signaling complex that induces dsDNA-induced type I IFN production. Such a molecular platform acts as a cellular sensor to recognize aberrant dsDNA in cases of viral infection and cell damage. This mechanism may also play roles in autoimmunity, transplantation rejection, gene-mediated vaccines, and other therapeutic applications. |
| first_indexed | 2024-12-11T01:27:02Z |
| format | Article |
| id | doaj.art-a1a971a3150347fab75b1f59f68a90ab |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T01:27:02Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a1a971a3150347fab75b1f59f68a90ab2022-12-22T01:25:29ZengFrontiers Media S.A.Frontiers in Genetics1664-80212013-05-01410.3389/fgene.2013.0009153362Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damageKouji eKobiyama0Kouji eKobiyama1Akira eKawashima2Akira eKawashima3Nao eJounai4Fumihiko eTakeshita5Ken J. Ishii6Ken J. Ishii7Tetsuhide eIto8Koichi eSuzuki9National Institute of Biomedical InnovationWPI immunology Frontier Research Center, Osaka UniversityNational Institute of Infectious DiseasesCenter for Molecular Medicine, Jichi Medical UniversityNational Institute of Biomedical InnovationNational Institute of Biomedical InnovationNational Institute of Biomedical InnovationWPI immunology Frontier Research Center, Osaka UniversityKyushu UniversityNational Institute of Infectious DiseasesHistones are essential components of chromatin structure, and histone modification plays an important role in various cellular functions including transcription, gene silencing and immunity. Histones also play distinct roles in extrachromosomal settings. Extrachromosomal histone H2B acts as a cytosolic sensor to detect double-stranded DNA (dsDNA) fragments derived from infectious agents or damaged cells to activate innate and acquired immune responses in various cell types. It also physically interacts with interferon (IFN)-β promoter stimulator 1 (IPS-1), an essential adaptor molecule that activates innate immunity, through COOH-terminal importin 9-related adaptor organizing histone H2B and IPS-1 (CIAO), resulting in a distinct signaling complex that induces dsDNA-induced type I IFN production. Such a molecular platform acts as a cellular sensor to recognize aberrant dsDNA in cases of viral infection and cell damage. This mechanism may also play roles in autoimmunity, transplantation rejection, gene-mediated vaccines, and other therapeutic applications.http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00091/fullDNA Damageepigenetic modificationsVirus infectionDNA sensorextrachromosomal histone |
| spellingShingle | Kouji eKobiyama Kouji eKobiyama Akira eKawashima Akira eKawashima Nao eJounai Fumihiko eTakeshita Ken J. Ishii Ken J. Ishii Tetsuhide eIto Koichi eSuzuki Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage Frontiers in Genetics DNA Damage epigenetic modifications Virus infection DNA sensor extrachromosomal histone |
| title | Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage |
| title_full | Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage |
| title_fullStr | Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage |
| title_full_unstemmed | Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage |
| title_short | Role of extrachromosomal histone H2B on recognition of DNA viruses and cell damage |
| title_sort | role of extrachromosomal histone h2b on recognition of dna viruses and cell damage |
| topic | DNA Damage epigenetic modifications Virus infection DNA sensor extrachromosomal histone |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00091/full |
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