Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID
Chronic obstructive pulmonary disease (COPD) is a risk factor for death in patients admitted to intensive care units (ICUs) for respiratory support. Previous reports suggested higher mortality in COPD patients with COVID-19. It is yet unknown whether patients with COPD were treated differently compa...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/18/5783 |
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| author | Athiwat Tripipitsiriwat Orawan Suppapueng David M. P. van Meenen Frederique Paulus Markus W. Hollmann Chaisith Sivakorn Marcus J. Schultz |
| author_facet | Athiwat Tripipitsiriwat Orawan Suppapueng David M. P. van Meenen Frederique Paulus Markus W. Hollmann Chaisith Sivakorn Marcus J. Schultz |
| author_sort | Athiwat Tripipitsiriwat |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a risk factor for death in patients admitted to intensive care units (ICUs) for respiratory support. Previous reports suggested higher mortality in COPD patients with COVID-19. It is yet unknown whether patients with COPD were treated differently compared to non-COPD patients. We compared the ventilation management and outcomes of invasive ventilation for COVID-19 in COPD patients versus non-COPD patients. This was a post hoc analysis of a nation-wide, observational study in the Netherlands. COPD patients were compared to non-COPD patients with respect to key ventilation parameters. The secondary endpoints included adjunctive treatments for refractory hypoxemia, and 28-day mortality. Of a total of 1090 patients, 88 (8.1%) were classified as having COPD. The ventilation parameters were not different between COPD patients and non-COPD patients, except for FiO<sub>2</sub>, which was higher in COPD patients. Prone positioning was applied more often in COPD patients. COPD patients had higher 28-day mortality than non-COPD patients. COPD had an independent association with 28-day mortality. In this cohort of patients who received invasive ventilation for COVID-19, only FiO<sub>2</sub> settings and the use of prone positioning were different between COPD patients and non-COPD patients. COPD patients had higher mortality than non-COPD patients. |
| first_indexed | 2024-03-10T22:37:24Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T22:37:24Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a1a9f691a1b74cc99406c58015f865f52023-11-19T11:17:17ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011218578310.3390/jcm12185783Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVIDAthiwat Tripipitsiriwat0Orawan Suppapueng1David M. P. van Meenen2Frederique Paulus3Markus W. Hollmann4Chaisith Sivakorn5Marcus J. Schultz6Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, ThailandDivision of Clinical Epidemiology, Department of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Intensive Care, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsIntensive Care Unit, University College London Hospital, London NW1 2BU, UKDepartment of Intensive Care, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The NetherlandsChronic obstructive pulmonary disease (COPD) is a risk factor for death in patients admitted to intensive care units (ICUs) for respiratory support. Previous reports suggested higher mortality in COPD patients with COVID-19. It is yet unknown whether patients with COPD were treated differently compared to non-COPD patients. We compared the ventilation management and outcomes of invasive ventilation for COVID-19 in COPD patients versus non-COPD patients. This was a post hoc analysis of a nation-wide, observational study in the Netherlands. COPD patients were compared to non-COPD patients with respect to key ventilation parameters. The secondary endpoints included adjunctive treatments for refractory hypoxemia, and 28-day mortality. Of a total of 1090 patients, 88 (8.1%) were classified as having COPD. The ventilation parameters were not different between COPD patients and non-COPD patients, except for FiO<sub>2</sub>, which was higher in COPD patients. Prone positioning was applied more often in COPD patients. COPD patients had higher 28-day mortality than non-COPD patients. COPD had an independent association with 28-day mortality. In this cohort of patients who received invasive ventilation for COVID-19, only FiO<sub>2</sub> settings and the use of prone positioning were different between COPD patients and non-COPD patients. COPD patients had higher mortality than non-COPD patients.https://www.mdpi.com/2077-0383/12/18/5783COPDARDSCOVID-19invasive ventilationventilation managementoutcome |
| spellingShingle | Athiwat Tripipitsiriwat Orawan Suppapueng David M. P. van Meenen Frederique Paulus Markus W. Hollmann Chaisith Sivakorn Marcus J. Schultz Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID Journal of Clinical Medicine COPD ARDS COVID-19 invasive ventilation ventilation management outcome |
| title | Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID |
| title_full | Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID |
| title_fullStr | Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID |
| title_full_unstemmed | Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID |
| title_short | Epidemiology, Ventilation Management and Outcomes of COPD Patients Receiving Invasive Ventilation for COVID-19—Insights from PRoVENT-COVID |
| title_sort | epidemiology ventilation management and outcomes of copd patients receiving invasive ventilation for covid 19 insights from provent covid |
| topic | COPD ARDS COVID-19 invasive ventilation ventilation management outcome |
| url | https://www.mdpi.com/2077-0383/12/18/5783 |
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