Trial protocol for SiroSkin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients

Trial protocol for SiroSkin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients

Abstract Background Keratinocyte carcinomas such as basal cell carcinomas and squamous cell carcinomas are a major burden affecting morbidity and mortality in solid organ transplant recipients (SOTRs). Best treatment includes frequent skin checks for early detection and surgery for high incidence of...

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Bibliographic Details
Main Authors: Lea Dousset, Daniel C. Chambers, Angela Webster, Nicole Isbel, Scott Campbell, Carla Duarte, Louisa Collins, Diona Damian, Anne Tseng, Emma Karlsen, Olga Victoria Ilinsky, Susan Brown, Helmut Schaider, H. Peter Soyer, Daniel Ariza Ospino, Sam Hogarth, Alvin H. Chong, Victoria Mar, Scott McKenzie, Douglas Gin, Pablo Fernandez-Penas, Johannes S. Kern, Katja Loewe, Edwige Roy, Alan Herschtal, Kiarash Khosrotehrani
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Trials
Subjects:
Sirolimus
Topical sirolimus
Skin cancer
Squamous cell carcinoma
Basal cell carcinoma
Actinic keratosis
Online Access:https://doi.org/10.1186/s13063-024-08619-3

Internet

https://doi.org/10.1186/s13063-024-08619-3

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