Gut microbiota and diabetes remission after metabolic surgery
Humans carry up to 200 bacterial species in the gastrointestinal tract. Important contribution of these genes is in carbohydrate degradation. The main task of the gut microbiota is digestion of food. The dominant gut bacteria are degradates of complex polysaccharides and releasing SCFA which are the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor
2018-01-01
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| Series: | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2018/1821-19251870022P.pdf |
| _version_ | 1811330790972194816 |
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| author | Polovina Snežana Šumarac-Dumanović Mirjana Kendereški Aleksandra Zorić Svetlana Stamenković-Pejković Danica Jeremić Danka Micić Dušan Micić Dragan |
| author_facet | Polovina Snežana Šumarac-Dumanović Mirjana Kendereški Aleksandra Zorić Svetlana Stamenković-Pejković Danica Jeremić Danka Micić Dušan Micić Dragan |
| author_sort | Polovina Snežana |
| collection | DOAJ |
| description | Humans carry up to 200 bacterial species in the gastrointestinal tract. Important contribution of these genes is in carbohydrate degradation. The main task of the gut microbiota is digestion of food. The dominant gut bacteria are degradates of complex polysaccharides and releasing SCFA which are the sources for energy, cholesterol synthesis and gluconeogenesis. The mutual interaction of gut microbiota and host immune system is necessary for maintaining their symbiotic relationship. Microbial compositions differ in different metabolic conditions. Firmicutes are dominant in obese subjects while Akkermansia muciniphila which protect against adiposity, low grade inflammation in adipose tissue and insulin resistance is reduced in this population. Intestinal dysbiosis is associated with insulin resistance and diabetes type 2. Betaproteobacteria was highly enriched in diabetic population. The ratio of Bacteriodetes to Firmicutes and the Bacteroides-Prevotella group to the C.coccoides-E.rectale group are reduced. Gastrointestinal rearrangements after RYGB promote substantial changes on the gut microbiota. Gut microbota manipulation in favor of Akkermansia spp. may contribute in antidiabetic effect of metformin and could be potential treatment for T2D. Changes in gut bacteria after RYGB (Roux-en-Y gastric bypass) alter the body weight independent of other effects of bariatric/metabolic surgery. Mechanism for diabetes remission after bariatric surgery is still not clear. Besides change in incretin secretion and bile acid recirculation, potential mechanism is change of gut microbiota content. Possible improvement of glucose regulation following bariatric surgery may be related to butyrate and propionate production by some bacteria species, which influence glucose metabolism independently of bile acids recirculation. |
| first_indexed | 2024-04-13T16:09:10Z |
| format | Article |
| id | doaj.art-a1ac805bd09342af9ec6085f299e6774 |
| institution | Directory Open Access Journal |
| issn | 1821-1925 2406-131X |
| language | English |
| last_indexed | 2024-04-13T16:09:10Z |
| publishDate | 2018-01-01 |
| publisher | Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor |
| record_format | Article |
| series | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| spelling | doaj.art-a1ac805bd09342af9ec6085f299e67742022-12-22T02:40:19ZengSpecijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma ZlatiborMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"1821-19252406-131X2018-01-01237022281821-19251870022PGut microbiota and diabetes remission after metabolic surgeryPolovina Snežana0Šumarac-Dumanović Mirjana1Kendereški Aleksandra2Zorić Svetlana3Stamenković-Pejković Danica4Jeremić Danka5Micić Dušan6Micić Dragan7Clinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade + Faculty of Pharmacy, Novi SadClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade + University of Belgrade, Medical FacultyClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade + University of Belgrade, Medical FacultyClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade Clinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade + University of Belgrade, Medical FacultyClinical Center of Serbia, Clinic for Endocrinology, Diabetes and Disease of Metabolism, Belgrade University of Belgrade, Medical Faculty + Clinical Center of Serbia, Emergency CenterUniversity of Belgrade, Medical Faculty + Serbian Academy of Sciences and Arts, Department of Medical SciencesHumans carry up to 200 bacterial species in the gastrointestinal tract. Important contribution of these genes is in carbohydrate degradation. The main task of the gut microbiota is digestion of food. The dominant gut bacteria are degradates of complex polysaccharides and releasing SCFA which are the sources for energy, cholesterol synthesis and gluconeogenesis. The mutual interaction of gut microbiota and host immune system is necessary for maintaining their symbiotic relationship. Microbial compositions differ in different metabolic conditions. Firmicutes are dominant in obese subjects while Akkermansia muciniphila which protect against adiposity, low grade inflammation in adipose tissue and insulin resistance is reduced in this population. Intestinal dysbiosis is associated with insulin resistance and diabetes type 2. Betaproteobacteria was highly enriched in diabetic population. The ratio of Bacteriodetes to Firmicutes and the Bacteroides-Prevotella group to the C.coccoides-E.rectale group are reduced. Gastrointestinal rearrangements after RYGB promote substantial changes on the gut microbiota. Gut microbota manipulation in favor of Akkermansia spp. may contribute in antidiabetic effect of metformin and could be potential treatment for T2D. Changes in gut bacteria after RYGB (Roux-en-Y gastric bypass) alter the body weight independent of other effects of bariatric/metabolic surgery. Mechanism for diabetes remission after bariatric surgery is still not clear. Besides change in incretin secretion and bile acid recirculation, potential mechanism is change of gut microbiota content. Possible improvement of glucose regulation following bariatric surgery may be related to butyrate and propionate production by some bacteria species, which influence glucose metabolism independently of bile acids recirculation.https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2018/1821-19251870022P.pdf |
| spellingShingle | Polovina Snežana Šumarac-Dumanović Mirjana Kendereški Aleksandra Zorić Svetlana Stamenković-Pejković Danica Jeremić Danka Micić Dušan Micić Dragan Gut microbiota and diabetes remission after metabolic surgery Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| title | Gut microbiota and diabetes remission after metabolic surgery |
| title_full | Gut microbiota and diabetes remission after metabolic surgery |
| title_fullStr | Gut microbiota and diabetes remission after metabolic surgery |
| title_full_unstemmed | Gut microbiota and diabetes remission after metabolic surgery |
| title_short | Gut microbiota and diabetes remission after metabolic surgery |
| title_sort | gut microbiota and diabetes remission after metabolic surgery |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2018/1821-19251870022P.pdf |
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