Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study
BackgroundLaparoscopic total gastrectomy (LTG) with Roux-en-Y (RY) is often accompanied by a series of complications. Uncut RY (URY) can effectively reduce Roux stasis syndrome (RSS) in laparoscopic distal gastrectomy. To determine whether totally LTG (TLTG) with URY for gastric cancer (GC) can repl...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1086966/full |
| _version_ | 1797979118165295104 |
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| author | Yizhen Chen Yizhen Chen Tao Zheng Tao Zheng Yifan Chen Yifan Chen Yuanyuan Zheng Yuanyuan Zheng Song Tan Song Tan Shaolin Liu Shaolin Liu Yuhang Zhou Yuhang Zhou Xiaojun Lin Xiaojun Lin Weijie Chen Weijie Chen Yulong Mi Shentao Lin Changshun Yang Weihua Li |
| author_facet | Yizhen Chen Yizhen Chen Tao Zheng Tao Zheng Yifan Chen Yifan Chen Yuanyuan Zheng Yuanyuan Zheng Song Tan Song Tan Shaolin Liu Shaolin Liu Yuhang Zhou Yuhang Zhou Xiaojun Lin Xiaojun Lin Weijie Chen Weijie Chen Yulong Mi Shentao Lin Changshun Yang Weihua Li |
| author_sort | Yizhen Chen |
| collection | DOAJ |
| description | BackgroundLaparoscopic total gastrectomy (LTG) with Roux-en-Y (RY) is often accompanied by a series of complications. Uncut RY (URY) can effectively reduce Roux stasis syndrome (RSS) in laparoscopic distal gastrectomy. To determine whether totally LTG (TLTG) with URY for gastric cancer (GC) can replace RY in short-term and long-term prognosis.MethodsThis comparative retrospective study selected GC patients from 2016 to 2022. The patients were divided into URY group and RY group. Cox multivariate proportional hazard regression analysis was used to explore the independent prognostic factors. Propensity score matching (PSM) was used to reduce bias.ResultsA total of 100 GC patients met the inclusion criteria. Compared to RY group, URY group showed significant advantages in operation time and length of hospital stay. In addition, URY group can significantly reduce short-term and long-term complications, especially RSS. The 1-, 3- and 5-year progression free survival (PFS) of URY group and RY group were 90.4% vs. 67.8% (P=0.005), 76.6% vs. 52.6% (P=0.009) and 76.6% vs. 32.8% (P<0.001), respectively. After PSM, the advantage of URY in PFS was verified again, while there was no significant difference in overall survival (OS) between the two groups. Cox multivariate analysis suggested that lower RSS was associated with better PFS.ConclusionsTLTG with URY for GC helps control disease progression, speed up recovery and reduce short and long-term complications, especially RSS. |
| first_indexed | 2024-04-11T05:33:59Z |
| format | Article |
| id | doaj.art-a1addecafef64f6db86b2c7210d6eff8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T05:33:59Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a1addecafef64f6db86b2c7210d6eff82022-12-22T15:49:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10869661086966Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative studyYizhen Chen0Yizhen Chen1Tao Zheng2Tao Zheng3Yifan Chen4Yifan Chen5Yuanyuan Zheng6Yuanyuan Zheng7Song Tan8Song Tan9Shaolin Liu10Shaolin Liu11Yuhang Zhou12Yuhang Zhou13Xiaojun Lin14Xiaojun Lin15Weijie Chen16Weijie Chen17Yulong Mi18Shentao Lin19Changshun Yang20Weihua Li21Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of VIP Clinic, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaBackgroundLaparoscopic total gastrectomy (LTG) with Roux-en-Y (RY) is often accompanied by a series of complications. Uncut RY (URY) can effectively reduce Roux stasis syndrome (RSS) in laparoscopic distal gastrectomy. To determine whether totally LTG (TLTG) with URY for gastric cancer (GC) can replace RY in short-term and long-term prognosis.MethodsThis comparative retrospective study selected GC patients from 2016 to 2022. The patients were divided into URY group and RY group. Cox multivariate proportional hazard regression analysis was used to explore the independent prognostic factors. Propensity score matching (PSM) was used to reduce bias.ResultsA total of 100 GC patients met the inclusion criteria. Compared to RY group, URY group showed significant advantages in operation time and length of hospital stay. In addition, URY group can significantly reduce short-term and long-term complications, especially RSS. The 1-, 3- and 5-year progression free survival (PFS) of URY group and RY group were 90.4% vs. 67.8% (P=0.005), 76.6% vs. 52.6% (P=0.009) and 76.6% vs. 32.8% (P<0.001), respectively. After PSM, the advantage of URY in PFS was verified again, while there was no significant difference in overall survival (OS) between the two groups. Cox multivariate analysis suggested that lower RSS was associated with better PFS.ConclusionsTLTG with URY for GC helps control disease progression, speed up recovery and reduce short and long-term complications, especially RSS.https://www.frontiersin.org/articles/10.3389/fonc.2022.1086966/fullgastric cancertotal gastrectomylaparoscopeuncut Roux-en-Ydigestive tract reconstruction |
| spellingShingle | Yizhen Chen Yizhen Chen Tao Zheng Tao Zheng Yifan Chen Yifan Chen Yuanyuan Zheng Yuanyuan Zheng Song Tan Song Tan Shaolin Liu Shaolin Liu Yuhang Zhou Yuhang Zhou Xiaojun Lin Xiaojun Lin Weijie Chen Weijie Chen Yulong Mi Shentao Lin Changshun Yang Weihua Li Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study Frontiers in Oncology gastric cancer total gastrectomy laparoscope uncut Roux-en-Y digestive tract reconstruction |
| title | Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study |
| title_full | Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study |
| title_fullStr | Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study |
| title_full_unstemmed | Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study |
| title_short | Totally laparoscopic total gastrectomy with Uncut Roux-en-Y for gastric cancer may improve prognosis: A propensity score matching comparative study |
| title_sort | totally laparoscopic total gastrectomy with uncut roux en y for gastric cancer may improve prognosis a propensity score matching comparative study |
| topic | gastric cancer total gastrectomy laparoscope uncut Roux-en-Y digestive tract reconstruction |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1086966/full |
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