Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals
Introduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepressant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) actions, which were described earlier (Spasov et al. 2...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2020-09-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/55142/download/pdf/ |
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| author | Dmitriy V. Maltsev Alexander A. Spasov Mikhail V. Miroshnikov Maria O. Skripka Ludmila N. Divaeva |
| author_facet | Dmitriy V. Maltsev Alexander A. Spasov Mikhail V. Miroshnikov Maria O. Skripka Ludmila N. Divaeva |
| author_sort | Dmitriy V. Maltsev |
| collection | DOAJ |
| description | Introduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepressant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) actions, which were described earlier (Spasov et al. 2020). 11-(4-tert-butylbenzyl)-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole hydrobromide (compound DAB-19) has evident anxiolytic, antidepressant and anticonvulsant effects. In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociability. Materials and methods: 112 outbred white animals (rats and mice) were used. Compound DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) were injected to the treatment groups. Using an Open Field (OF) test, we evaluated a spontaneous motor activity, a search activity of mice and a degree of their emotionality. During a Marble Burying (MB) test, we monitored anxiolytic and anticompulsive effects of DAB-19. Using a Resident-intruder (RI) test, we evaluated a degree of aggression in the experimental animals, properties of their social interaction, as well as defensive and individual behavior. Results and discussion: Compound DAB-19 has positive influence on the search activity, mood stabilizing activity and antiaggressive actions. Administration of both DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) reduced anxiety-like behavior in OP, RI and MB tests, as indicated by a significantly increased number of entries to the center of OP; a decreased number of marbles buried in MB and reduced aggressive behavior in RI. It was stated that using DAB-19 leads to a decrease in affective reactions of the animals – aggression, obsessive-compulsive behavior, neurotic condition and emotional instability. Conclusions: The compound (DAB-19) produces anxiolytic-like effects, compared with those of diazepam, in various anxiety paradigms. |
| first_indexed | 2024-03-09T09:14:04Z |
| format | Article |
| id | doaj.art-a1b2e8ae243644678d86dc520a8b6bf3 |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:14:04Z |
| publishDate | 2020-09-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-a1b2e8ae243644678d86dc520a8b6bf32023-12-02T07:50:12ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2020-09-016391410.3897/rrpharmacology.6.5514255142Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animalsDmitriy V. Maltsev0Alexander A. Spasov1Mikhail V. Miroshnikov2Maria O. Skripka3Ludmila N. Divaeva4Volgograd Medical Research CenterVolgograd Medical Research CenterVolgograd State Medical UniversityVolgograd State Medical UniversitySouthern Federal UniversityIntroduction: Diazepino[1,2-a]benzimidazole derivatives showed anxiolytic (EPM, L/D box, Vogel test), antidepressant (Tail Suspension test, Porsolt test), anticonvulsant (Pentylenetetrazole-Induced seizures) and analgesic (Tail-Flick, Hot Plate) actions, which were described earlier (Spasov et al. 2020). 11-(4-tert-butylbenzyl)-2,3,4,5-tetrahydro[1,3]diazepino[1,2-a]benzimidazole hydrobromide (compound DAB-19) has evident anxiolytic, antidepressant and anticonvulsant effects. In the present study, compound DAB-19 was screened for its influence on animals` behavior patterns, such as aggression, obsessive-compulsive behavior, emotional lability, and unsociability. Materials and methods: 112 outbred white animals (rats and mice) were used. Compound DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) were injected to the treatment groups. Using an Open Field (OF) test, we evaluated a spontaneous motor activity, a search activity of mice and a degree of their emotionality. During a Marble Burying (MB) test, we monitored anxiolytic and anticompulsive effects of DAB-19. Using a Resident-intruder (RI) test, we evaluated a degree of aggression in the experimental animals, properties of their social interaction, as well as defensive and individual behavior. Results and discussion: Compound DAB-19 has positive influence on the search activity, mood stabilizing activity and antiaggressive actions. Administration of both DAB-19 (2.34 mg/kg, p.o.) and diazepam (2 mg/kg, p.o.) reduced anxiety-like behavior in OP, RI and MB tests, as indicated by a significantly increased number of entries to the center of OP; a decreased number of marbles buried in MB and reduced aggressive behavior in RI. It was stated that using DAB-19 leads to a decrease in affective reactions of the animals – aggression, obsessive-compulsive behavior, neurotic condition and emotional instability. Conclusions: The compound (DAB-19) produces anxiolytic-like effects, compared with those of diazepam, in various anxiety paradigms.https://rrpharmacology.pensoft.net/article/55142/download/pdf/ |
| spellingShingle | Dmitriy V. Maltsev Alexander A. Spasov Mikhail V. Miroshnikov Maria O. Skripka Ludmila N. Divaeva Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals Research Results in Pharmacology |
| title | Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals |
| title_full | Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals |
| title_fullStr | Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals |
| title_full_unstemmed | Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals |
| title_short | Influence of Diazepino[1,2-a]benzimidazole derivative (DAB-19) on behavioral aspects of animals |
| title_sort | influence of diazepino 1 2 a benzimidazole derivative dab 19 on behavioral aspects of animals |
| url | https://rrpharmacology.pensoft.net/article/55142/download/pdf/ |
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