Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the Na<sub>V</sub>1.8 Channel Activation Gating System

Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the Na<sub>V</sub>1.8 Channel Activation Gating System

The present work continues our recent series of articles that aim to elucidate the ligand–receptor binding mechanism of short cationic peptides to the Na<sub>V</sub>1.8 channel in the nociceptive neuron. The applied methodological approach has involved several methods: the patch-clamp ex...

Full description

Bibliographic Details
Main Authors: Arina D. Kalinina, Ilya V. Rogachevskii, Dmitriy M. Samosvat, Georgy G. Zegrya, Irina P. Butkevich, Viktor A. Mikhailenko, Vera B. Plakhova, Valentina A. Penniyaynen, Svetlana A. Podzorova, Boris V. Krylov
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Life
Subjects:
lysine-containing peptides
Na<sub>V</sub>1.8 channel
patch-clamp method
organotypic tissue culture method
formalin test
conformational analysis
Online Access:https://www.mdpi.com/2075-1729/13/9/1800

Internet

https://www.mdpi.com/2075-1729/13/9/1800

Similar Items