Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
ZhongHua Lei,1,2,* Liu Ouyang,3,* Yong Gong,1 ZhaoZhen Wang,1 Bo Yu1 1Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People’s Republic of China; 2Department of Orthopedics, The Sixth Peoples Hospital of Huizhou, Huizhou 516211, People&rsquo...
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| Format: | Article |
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Dove Medical Press
2020-04-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/effect-of-eriodictyol-on-collagen-induced-arthritis-in-rats-by-akthif--peer-reviewed-article-DDDT |
| _version_ | 1818110554432077824 |
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| author | Lei Z Ouyang L Gong Y Wang Z Yu B |
| author_facet | Lei Z Ouyang L Gong Y Wang Z Yu B |
| author_sort | Lei Z |
| collection | DOAJ |
| description | ZhongHua Lei,1,2,* Liu Ouyang,3,* Yong Gong,1 ZhaoZhen Wang,1 Bo Yu1 1Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People’s Republic of China; 2Department of Orthopedics, The Sixth Peoples Hospital of Huizhou, Huizhou 516211, People’s Republic of China; 3Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Yu Email yubozj@yeah.netPurpose: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis.Methods: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats.Results: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells.Conclusion: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.Keywords: Eriodictyol, arthritis, inflammation, Akt/HIF-1α pathway |
| first_indexed | 2024-12-11T02:49:00Z |
| format | Article |
| id | doaj.art-a1b4ea3b8b5a41bc870132bc60def3ca |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-11T02:49:00Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-a1b4ea3b8b5a41bc870132bc60def3ca2022-12-22T01:23:22ZengDove Medical PressDrug Design, Development and Therapy1177-88812020-04-01Volume 141633163953424Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α PathwayLei ZOuyang LGong YWang ZYu BZhongHua Lei,1,2,* Liu Ouyang,3,* Yong Gong,1 ZhaoZhen Wang,1 Bo Yu1 1Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, People’s Republic of China; 2Department of Orthopedics, The Sixth Peoples Hospital of Huizhou, Huizhou 516211, People’s Republic of China; 3Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Yu Email yubozj@yeah.netPurpose: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis.Methods: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats.Results: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells.Conclusion: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.Keywords: Eriodictyol, arthritis, inflammation, Akt/HIF-1α pathwayhttps://www.dovepress.com/effect-of-eriodictyol-on-collagen-induced-arthritis-in-rats-by-akthif--peer-reviewed-article-DDDTeriodictyolarthritisinflammationakt/hif-1α pathway |
| spellingShingle | Lei Z Ouyang L Gong Y Wang Z Yu B Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway Drug Design, Development and Therapy eriodictyol arthritis inflammation akt/hif-1α pathway |
| title | Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway |
| title_full | Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway |
| title_fullStr | Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway |
| title_full_unstemmed | Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway |
| title_short | Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway |
| title_sort | effect of eriodictyol on collagen induced arthritis in rats by akt hif 1 alpha pathway |
| topic | eriodictyol arthritis inflammation akt/hif-1α pathway |
| url | https://www.dovepress.com/effect-of-eriodictyol-on-collagen-induced-arthritis-in-rats-by-akthif--peer-reviewed-article-DDDT |
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