Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV
HIV infection may affect the immune response to vaccination. Here the authors show that humoral response in persons living with HIV after the third dose of a SARS-CoV-2 vaccine is strong and higher than that achieved with the second dose, while cell-mediated immunity remains stable.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32263-7 |
| _version_ | 1811183291849506816 |
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| author | Alessandra Vergori Alessandro Cozzi Lepri Stefania Cicalini Giulia Matusali Veronica Bordoni Simone Lanini Silvia Meschi Roberta Iannazzo Valentina Mazzotta Francesca Colavita Ilaria Mastrorosa Eleonora Cimini Davide Mariotti Lydia De Pascale Alessandra Marani Paola Gallì AnnaRosa Garbuglia Concetta Castilletti Vincenzo Puro Chiara Agrati Enrico Girardi Francesco Vaia Andrea Antinori HIV-VAC study group |
| author_facet | Alessandra Vergori Alessandro Cozzi Lepri Stefania Cicalini Giulia Matusali Veronica Bordoni Simone Lanini Silvia Meschi Roberta Iannazzo Valentina Mazzotta Francesca Colavita Ilaria Mastrorosa Eleonora Cimini Davide Mariotti Lydia De Pascale Alessandra Marani Paola Gallì AnnaRosa Garbuglia Concetta Castilletti Vincenzo Puro Chiara Agrati Enrico Girardi Francesco Vaia Andrea Antinori HIV-VAC study group |
| author_sort | Alessandra Vergori |
| collection | DOAJ |
| description | HIV infection may affect the immune response to vaccination. Here the authors show that humoral response in persons living with HIV after the third dose of a SARS-CoV-2 vaccine is strong and higher than that achieved with the second dose, while cell-mediated immunity remains stable. |
| first_indexed | 2024-04-11T09:45:36Z |
| format | Article |
| id | doaj.art-a1b7cc1d3b744e3dba2671ba692bdfda |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T09:45:36Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a1b7cc1d3b744e3dba2671ba692bdfda2022-12-22T04:31:05ZengNature PortfolioNature Communications2041-17232022-08-0113111310.1038/s41467-022-32263-7Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIVAlessandra Vergori0Alessandro Cozzi Lepri1Stefania Cicalini2Giulia Matusali3Veronica Bordoni4Simone Lanini5Silvia Meschi6Roberta Iannazzo7Valentina Mazzotta8Francesca Colavita9Ilaria Mastrorosa10Eleonora Cimini11Davide Mariotti12Lydia De Pascale13Alessandra Marani14Paola Gallì15AnnaRosa Garbuglia16Concetta Castilletti17Vincenzo Puro18Chiara Agrati19Enrico Girardi20Francesco Vaia21Andrea Antinori22HIV-VAC study groupHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSCentre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME), Institute for Global Health, UCLHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Cellular Immunology and Clinical Pharmacology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Cellular Immunology and Clinical Pharmacology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Cellular Immunology and Clinical Pharmacology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHealth Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHealth Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSRisk Management Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSLaboratory of Cellular Immunology and Clinical Pharmacology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSScientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHealth Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV/AIDS Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCSHIV infection may affect the immune response to vaccination. Here the authors show that humoral response in persons living with HIV after the third dose of a SARS-CoV-2 vaccine is strong and higher than that achieved with the second dose, while cell-mediated immunity remains stable.https://doi.org/10.1038/s41467-022-32263-7 |
| spellingShingle | Alessandra Vergori Alessandro Cozzi Lepri Stefania Cicalini Giulia Matusali Veronica Bordoni Simone Lanini Silvia Meschi Roberta Iannazzo Valentina Mazzotta Francesca Colavita Ilaria Mastrorosa Eleonora Cimini Davide Mariotti Lydia De Pascale Alessandra Marani Paola Gallì AnnaRosa Garbuglia Concetta Castilletti Vincenzo Puro Chiara Agrati Enrico Girardi Francesco Vaia Andrea Antinori HIV-VAC study group Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV Nature Communications |
| title | Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV |
| title_full | Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV |
| title_fullStr | Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV |
| title_full_unstemmed | Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV |
| title_short | Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV |
| title_sort | immunogenicity to covid 19 mrna vaccine third dose in people living with hiv |
| url | https://doi.org/10.1038/s41467-022-32263-7 |
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