Uveal Melanoma Metastasis to the Thyroid
Background. Around 1.2 to 3.1% of thyroid malignancies are due to metastasis. Among them, cutaneous malignant melanomas constitute 4% of malignancy metastasized to the thyroid. Uveal melanoma is uncommon, and its metastasis to the thyroid has only rarely been reported. Hereby, we describe an unusual...
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| 格式: | 文件 |
| 语言: | English |
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Hindawi Limited
2023-01-01
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| 丛编: | Case Reports in Endocrinology |
| 在线阅读: | http://dx.doi.org/10.1155/2023/2118672 |
| _version_ | 1827085829104730112 |
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| author | Rokshana R. Thanadar Uzma M. Siddiqui Shi Bai Runhua Hou |
| author_facet | Rokshana R. Thanadar Uzma M. Siddiqui Shi Bai Runhua Hou |
| author_sort | Rokshana R. Thanadar |
| collection | DOAJ |
| description | Background. Around 1.2 to 3.1% of thyroid malignancies are due to metastasis. Among them, cutaneous malignant melanomas constitute 4% of malignancy metastasized to the thyroid. Uveal melanoma is uncommon, and its metastasis to the thyroid has only rarely been reported. Hereby, we describe an unusual case of uveal melanoma metastasized to the thyroid and discuss the concept of correct diagnosis. Case Report. During a routine ophthalmological examination, an 86-year-old Caucasian female was found to have retinal detachment secondary to choroidal melanoma. She was treated with gamma knife which resulted in reduction of tumor size. Three months later, she was noted to have a goiter on physical examination. Follow-up thyroid ultrasonography demonstrated numerous vascularized nodules in both lobes. The fine needle aspiration (FNA) of the left dominant nodule was indeterminate the first time and nondiagnostic the second time. FNA of the right dominant nodule was nondiagnostic twice but showed malignant cells the third time. Subsequent immunohistochemistry staining of the FNA sample from the right thyroid nodule confirmed a profile consistent with malignant melanoma. Conclusion. It should be kept in mind that a thyroid nodule detected in a patient with a diagnosis of uveal melanoma can be metastasis and that uveal melanoma diagnosis should be taken into account for the examination of the thyroid tumors of these patients. It is important to employ immunohistochemical staining FNA examination of the patient with such tumors for markers associated with a patient’s known malignancy to facilitate diagnosis. |
| first_indexed | 2024-03-12T13:38:32Z |
| format | Article |
| id | doaj.art-a1b7d19cb3fe4a8e81903bfecedd9fb0 |
| institution | Directory Open Access Journal |
| issn | 2090-651X |
| language | English |
| last_indexed | 2025-03-20T04:27:09Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj.art-a1b7d19cb3fe4a8e81903bfecedd9fb02024-10-03T05:47:35ZengHindawi LimitedCase Reports in Endocrinology2090-651X2023-01-01202310.1155/2023/2118672Uveal Melanoma Metastasis to the ThyroidRokshana R. Thanadar0Uzma M. Siddiqui1Shi Bai2Runhua Hou3Endocrinology and Diabetes Center of TidewaterEndocrinologyDepartment of PathologyThyroid AssociatesBackground. Around 1.2 to 3.1% of thyroid malignancies are due to metastasis. Among them, cutaneous malignant melanomas constitute 4% of malignancy metastasized to the thyroid. Uveal melanoma is uncommon, and its metastasis to the thyroid has only rarely been reported. Hereby, we describe an unusual case of uveal melanoma metastasized to the thyroid and discuss the concept of correct diagnosis. Case Report. During a routine ophthalmological examination, an 86-year-old Caucasian female was found to have retinal detachment secondary to choroidal melanoma. She was treated with gamma knife which resulted in reduction of tumor size. Three months later, she was noted to have a goiter on physical examination. Follow-up thyroid ultrasonography demonstrated numerous vascularized nodules in both lobes. The fine needle aspiration (FNA) of the left dominant nodule was indeterminate the first time and nondiagnostic the second time. FNA of the right dominant nodule was nondiagnostic twice but showed malignant cells the third time. Subsequent immunohistochemistry staining of the FNA sample from the right thyroid nodule confirmed a profile consistent with malignant melanoma. Conclusion. It should be kept in mind that a thyroid nodule detected in a patient with a diagnosis of uveal melanoma can be metastasis and that uveal melanoma diagnosis should be taken into account for the examination of the thyroid tumors of these patients. It is important to employ immunohistochemical staining FNA examination of the patient with such tumors for markers associated with a patient’s known malignancy to facilitate diagnosis.http://dx.doi.org/10.1155/2023/2118672 |
| spellingShingle | Rokshana R. Thanadar Uzma M. Siddiqui Shi Bai Runhua Hou Uveal Melanoma Metastasis to the Thyroid Case Reports in Endocrinology |
| title | Uveal Melanoma Metastasis to the Thyroid |
| title_full | Uveal Melanoma Metastasis to the Thyroid |
| title_fullStr | Uveal Melanoma Metastasis to the Thyroid |
| title_full_unstemmed | Uveal Melanoma Metastasis to the Thyroid |
| title_short | Uveal Melanoma Metastasis to the Thyroid |
| title_sort | uveal melanoma metastasis to the thyroid |
| url | http://dx.doi.org/10.1155/2023/2118672 |
| work_keys_str_mv | AT rokshanarthanadar uvealmelanomametastasistothethyroid AT uzmamsiddiqui uvealmelanomametastasistothethyroid AT shibai uvealmelanomametastasistothethyroid AT runhuahou uvealmelanomametastasistothethyroid |