Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents
Fe(III) complexes have again attracted much attention for application as MRI contrast agents in recent years due to their high thermodynamic stability, low long-term toxicity, and large relaxivity at a higher magnetic field. This mini-review covers the recent progress on low-molecular-weight Fe(III)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/14/4573 |
| _version_ | 1797433268041154560 |
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| author | Shangjun Chen Lu An Shiping Yang |
| author_facet | Shangjun Chen Lu An Shiping Yang |
| author_sort | Shangjun Chen |
| collection | DOAJ |
| description | Fe(III) complexes have again attracted much attention for application as MRI contrast agents in recent years due to their high thermodynamic stability, low long-term toxicity, and large relaxivity at a higher magnetic field. This mini-review covers the recent progress on low-molecular-weight Fe(III) complexes, which have been considered as one of the promising alternatives to clinically used Gd(III)-based contrast agents. Two kinds of complexes including mononuclear Fe(III) complexes and multinuclear Fe(III) complexes are summarized in sequence, with a specific highlight of the structural relationships between the complexes and their relaxivity and thermodynamic stability. In additional, the future perspectives for the design of low-molecular-weight Fe(III) complexes for MRI contrast agents are suggested. |
| first_indexed | 2024-03-09T10:14:35Z |
| format | Article |
| id | doaj.art-a1bab2ae98284062a096cd3e81a10333 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T10:14:35Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a1bab2ae98284062a096cd3e81a103332023-12-01T22:30:10ZengMDPI AGMolecules1420-30492022-07-012714457310.3390/molecules27144573Low-Molecular-Weight Fe(III) Complexes for MRI Contrast AgentsShangjun Chen0Lu An1Shiping Yang2Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, ChinaShanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaKey Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, ChinaFe(III) complexes have again attracted much attention for application as MRI contrast agents in recent years due to their high thermodynamic stability, low long-term toxicity, and large relaxivity at a higher magnetic field. This mini-review covers the recent progress on low-molecular-weight Fe(III) complexes, which have been considered as one of the promising alternatives to clinically used Gd(III)-based contrast agents. Two kinds of complexes including mononuclear Fe(III) complexes and multinuclear Fe(III) complexes are summarized in sequence, with a specific highlight of the structural relationships between the complexes and their relaxivity and thermodynamic stability. In additional, the future perspectives for the design of low-molecular-weight Fe(III) complexes for MRI contrast agents are suggested.https://www.mdpi.com/1420-3049/27/14/4573Fe(III) complexesMRI contrast agentsrelaxivitythermodynamic stabilitystructure relationship |
| spellingShingle | Shangjun Chen Lu An Shiping Yang Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents Molecules Fe(III) complexes MRI contrast agents relaxivity thermodynamic stability structure relationship |
| title | Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents |
| title_full | Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents |
| title_fullStr | Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents |
| title_full_unstemmed | Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents |
| title_short | Low-Molecular-Weight Fe(III) Complexes for MRI Contrast Agents |
| title_sort | low molecular weight fe iii complexes for mri contrast agents |
| topic | Fe(III) complexes MRI contrast agents relaxivity thermodynamic stability structure relationship |
| url | https://www.mdpi.com/1420-3049/27/14/4573 |
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