The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice
The dietary intervention has demonstrated effectiveness in improving hyperlipidemia and obesity. Woody edible oils are rich in unsaturated fatty acids (UFAs) that could positively affect lipid metabolism. In this study, the blended oil (BLO), a balanced UFA supplement, constituted by Zanthoxylum bun...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1203932/full |
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| author | Xi Chen Xi Chen Jingqi Ran Muhammad Mazhar Muhammad Mazhar Yong Zhu Yichen Lin Likang Qin Likang Qin Song Miao |
| author_facet | Xi Chen Xi Chen Jingqi Ran Muhammad Mazhar Muhammad Mazhar Yong Zhu Yichen Lin Likang Qin Likang Qin Song Miao |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | The dietary intervention has demonstrated effectiveness in improving hyperlipidemia and obesity. Woody edible oils are rich in unsaturated fatty acids (UFAs) that could positively affect lipid metabolism. In this study, the blended oil (BLO), a balanced UFA supplement, constituted by Zanthoxylum bungeanum (Chinese Red Pepper) seed oil, walnut (Juglans regia) oil, camellia (Camema oleifera) seed oil and perilla (Perilla frutescens) seed oil was established referring to the Chinese dietary reference intakes, in which the ratios of monounsaturated/polyunsaturated fatty acids and ω-6/ω-3 polyunsaturated fatty acids were 1:1 and 4:1, respectively. The BLO was administrated to KM mice fed a high-fat diet (HFD) by gavage every day at a dose of 3.0 mL/kg·bw for 10 weeks to assess its effects on serum lipid levels, liver antioxidant activities and gut microbial composition. The results showed that the BLO improved hepatic steatosis, liver oxidative stress, and serum lipid levels. Additionally, there was an increased abundance of Lactobacillus, Allobaculum, and Blautia, along with a decreased abundance of Staphylococcus in cecal contents. These changes were found to be positively correlated with the metabolic improvements, as indicated by Spearman’s correlation analysis. These findings implied the practicality of the balanced unsaturated fatty acid consumption in preventing hyperlipidemia and obesity. |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T22:45:26Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-a1be36f6b4034cd387572c0b45f7d0562023-07-21T06:26:48ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.12039321203932The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet miceXi Chen0Xi Chen1Jingqi Ran2Muhammad Mazhar3Muhammad Mazhar4Yong Zhu5Yichen Lin6Likang Qin7Likang Qin8Song Miao9Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences/Institute of Agro-Bioengineering, Guizhou University, Guiyang, ChinaDepartment of Laboratory Medicine, Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, ChinaKey Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences/Institute of Agro-Bioengineering, Guizhou University, Guiyang, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, ChinaTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, IrelandKey Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences/Institute of Agro-Bioengineering, Guizhou University, Guiyang, ChinaSchool of Liquor and Food Engineering, Guizhou University, Guiyang, ChinaTeagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, IrelandThe dietary intervention has demonstrated effectiveness in improving hyperlipidemia and obesity. Woody edible oils are rich in unsaturated fatty acids (UFAs) that could positively affect lipid metabolism. In this study, the blended oil (BLO), a balanced UFA supplement, constituted by Zanthoxylum bungeanum (Chinese Red Pepper) seed oil, walnut (Juglans regia) oil, camellia (Camema oleifera) seed oil and perilla (Perilla frutescens) seed oil was established referring to the Chinese dietary reference intakes, in which the ratios of monounsaturated/polyunsaturated fatty acids and ω-6/ω-3 polyunsaturated fatty acids were 1:1 and 4:1, respectively. The BLO was administrated to KM mice fed a high-fat diet (HFD) by gavage every day at a dose of 3.0 mL/kg·bw for 10 weeks to assess its effects on serum lipid levels, liver antioxidant activities and gut microbial composition. The results showed that the BLO improved hepatic steatosis, liver oxidative stress, and serum lipid levels. Additionally, there was an increased abundance of Lactobacillus, Allobaculum, and Blautia, along with a decreased abundance of Staphylococcus in cecal contents. These changes were found to be positively correlated with the metabolic improvements, as indicated by Spearman’s correlation analysis. These findings implied the practicality of the balanced unsaturated fatty acid consumption in preventing hyperlipidemia and obesity.https://www.frontiersin.org/articles/10.3389/fnut.2023.1203932/fullwoody edible oilunsaturated fatty acidblended oillipid metabolismgut microbiota |
| spellingShingle | Xi Chen Xi Chen Jingqi Ran Muhammad Mazhar Muhammad Mazhar Yong Zhu Yichen Lin Likang Qin Likang Qin Song Miao The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice Frontiers in Nutrition woody edible oil unsaturated fatty acid blended oil lipid metabolism gut microbiota |
| title | The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice |
| title_full | The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice |
| title_fullStr | The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice |
| title_full_unstemmed | The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice |
| title_short | The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice |
| title_sort | balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high fat diet mice |
| topic | woody edible oil unsaturated fatty acid blended oil lipid metabolism gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1203932/full |
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