COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation
Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Met...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/12/1611 |
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| author | Sergio Bagnato Manfredi Ferraro Cristina Boccagni Gianluca Battaglia Tiziana D’Agostino Caterina Prestandrea Marina Angela Bellavia Francesca Rubino |
| author_facet | Sergio Bagnato Manfredi Ferraro Cristina Boccagni Gianluca Battaglia Tiziana D’Agostino Caterina Prestandrea Marina Angela Bellavia Francesca Rubino |
| author_sort | Sergio Bagnato |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning. |
| first_indexed | 2024-03-10T04:32:58Z |
| format | Article |
| id | doaj.art-a1beac78deaf4c0d950be54fe2c70810 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T04:32:58Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a1beac78deaf4c0d950be54fe2c708102023-11-23T04:02:02ZengMDPI AGBrain Sciences2076-34252021-12-011112161110.3390/brainsci11121611COVID-19 Neuromuscular Involvement in Post-Acute RehabilitationSergio Bagnato0Manfredi Ferraro1Cristina Boccagni2Gianluca Battaglia3Tiziana D’Agostino4Caterina Prestandrea5Marina Angela Bellavia6Francesca Rubino7Unit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Cardiac and Pulmonary Rehabilitation, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyUnit of Neurophysiology, Rehabilitation Department, Giuseppe Giglio Foundation, 90015 Cefalù, ItalyBackground: Coronavirus disease 2019 (COVID-19) is associated with muscle and nerve injuries as a consequence of prolonged critical illness or the infection itself. In this study, we evaluated neuromuscular involvement in patients who underwent post-acute intensive rehabilitation after COVID-19. Methods: Clinical and neurophysiological evaluations, including nerve conduction studies and electromyography, were performed on 21 consecutive patients admitted for rehabilitation after COVID-19. Results: Clinical signs suggesting muscle or nerve involvement (weakness, reduced deep tendon reflexes, impaired sensitivity, abnormal gait) were found in 19 patients. Neurophysiological examinations confirmed neuromuscular involvement in 17 patients: a likely association of critical illness myopathy (CIM) and critical illness polyneuropathy (CIP) was found in 5 patients; CIM alone was found in 4 patients; axonal sensory-motor polyneuropathy was found in 4 patients (CIP in 2 patients, metabolic polyneuropathy in 2 patients); Guillain-Barré syndrome was found in 2 patients (classical demyelinating sensory-motor polyneuropathy and acute motor axonal neuropathy, respectively); peroneal nerve injury was found in 1 patient; and pre-existing L4 radiculopathy was found in 1 patient. Conclusions: Neuromuscular involvement is a very common finding among patients admitted for rehabilitation after COVID-19, and proper investigation should be conducted when muscle or nerve injury is suspected for adequate rehabilitative strategy planning.https://www.mdpi.com/2076-3425/11/12/1611critical illness myopathycritical illness polyneuropathyGuillain-Barré syndromeacute motor axonal neuropathydemyelinating sensory-motor polyneuropathypositioning nerve injury |
| spellingShingle | Sergio Bagnato Manfredi Ferraro Cristina Boccagni Gianluca Battaglia Tiziana D’Agostino Caterina Prestandrea Marina Angela Bellavia Francesca Rubino COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation Brain Sciences critical illness myopathy critical illness polyneuropathy Guillain-Barré syndrome acute motor axonal neuropathy demyelinating sensory-motor polyneuropathy positioning nerve injury |
| title | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
| title_full | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
| title_fullStr | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
| title_full_unstemmed | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
| title_short | COVID-19 Neuromuscular Involvement in Post-Acute Rehabilitation |
| title_sort | covid 19 neuromuscular involvement in post acute rehabilitation |
| topic | critical illness myopathy critical illness polyneuropathy Guillain-Barré syndrome acute motor axonal neuropathy demyelinating sensory-motor polyneuropathy positioning nerve injury |
| url | https://www.mdpi.com/2076-3425/11/12/1611 |
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