Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer
Abstract Introduction Macrophages are innate immune cells that are associated with extensive phenotypic and functional plasticity and contribute to normal development, tissue homeostasis, and diseases such as cancer. In this review, we discuss the heterogeneity of tissue resident macrophages in the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.7053 |
| _version_ | 1797216986144440320 |
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| author | Alexis K. Elfstrum Aditi S. Bapat Kathryn L. Schwertfeger |
| author_facet | Alexis K. Elfstrum Aditi S. Bapat Kathryn L. Schwertfeger |
| author_sort | Alexis K. Elfstrum |
| collection | DOAJ |
| description | Abstract Introduction Macrophages are innate immune cells that are associated with extensive phenotypic and functional plasticity and contribute to normal development, tissue homeostasis, and diseases such as cancer. In this review, we discuss the heterogeneity of tissue resident macrophages in the normal mammary gland and tumor‐associated macrophages in breast cancer. Tissue resident macrophages are required for mammary gland development, where they have been implicated in promoting extracellular matrix remodeling, apoptotic clearance, and cellular crosstalk. In the context of cancer, tumor‐associated macrophages are key drivers of growth and metastasis via their ability to promote matrix remodeling, angiogenesis, lymphangiogenesis, and immunosuppression. Method We identified and summarized studies in Pubmed that describe the phenotypic and functional heterogeneity of macrophages and the implications of targeting individual subsets, specifically in the context of mammary gland development and breast cancer. We also identified and summarized recent studies using single‐cell RNA sequencing to identify and describe macrophage subsets in human breast cancer samples. Results Advances in single‐cell RNA sequencing technologies have yielded nuances in macrophage heterogeneity, with numerous macrophage subsets identified in both the normal mammary gland and breast cancer tissue. Macrophage subsets contribute to mammary gland development and breast cancer progression in differing ways, and emerging studies highlight a role for spatial localization in modulating their phenotype and function. Conclusion Understanding macrophage heterogeneity and the unique functions of each subset in both normal mammary gland development and breast cancer progression may lead to more promising targets for the treatment of breast cancer. |
| first_indexed | 2024-03-07T15:43:47Z |
| format | Article |
| id | doaj.art-a1bf40ebfd2b40fb97186b4dd2de8003 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T11:54:40Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a1bf40ebfd2b40fb97186b4dd2de80032024-04-09T05:45:48ZengWileyCancer Medicine2045-76342024-02-01133n/an/a10.1002/cam4.7053Defining and targeting macrophage heterogeneity in the mammary gland and breast cancerAlexis K. Elfstrum0Aditi S. Bapat1Kathryn L. Schwertfeger2Microbiology, Immunology, and Cancer Biology Graduate Program University of Minnesota Minneapolis Minnesota USAMolecular Pharmacology and Therapeutics Graduate Program University of Minnesota Minneapolis Minnesota USADepartment of Laboratory Medicine and Pathology University of Minnesota Minneapolis Minnesota USAAbstract Introduction Macrophages are innate immune cells that are associated with extensive phenotypic and functional plasticity and contribute to normal development, tissue homeostasis, and diseases such as cancer. In this review, we discuss the heterogeneity of tissue resident macrophages in the normal mammary gland and tumor‐associated macrophages in breast cancer. Tissue resident macrophages are required for mammary gland development, where they have been implicated in promoting extracellular matrix remodeling, apoptotic clearance, and cellular crosstalk. In the context of cancer, tumor‐associated macrophages are key drivers of growth and metastasis via their ability to promote matrix remodeling, angiogenesis, lymphangiogenesis, and immunosuppression. Method We identified and summarized studies in Pubmed that describe the phenotypic and functional heterogeneity of macrophages and the implications of targeting individual subsets, specifically in the context of mammary gland development and breast cancer. We also identified and summarized recent studies using single‐cell RNA sequencing to identify and describe macrophage subsets in human breast cancer samples. Results Advances in single‐cell RNA sequencing technologies have yielded nuances in macrophage heterogeneity, with numerous macrophage subsets identified in both the normal mammary gland and breast cancer tissue. Macrophage subsets contribute to mammary gland development and breast cancer progression in differing ways, and emerging studies highlight a role for spatial localization in modulating their phenotype and function. Conclusion Understanding macrophage heterogeneity and the unique functions of each subset in both normal mammary gland development and breast cancer progression may lead to more promising targets for the treatment of breast cancer.https://doi.org/10.1002/cam4.7053breast cancerLYVE‐1macrophagemammary glandTREM2 |
| spellingShingle | Alexis K. Elfstrum Aditi S. Bapat Kathryn L. Schwertfeger Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer Cancer Medicine breast cancer LYVE‐1 macrophage mammary gland TREM2 |
| title | Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| title_full | Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| title_fullStr | Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| title_full_unstemmed | Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| title_short | Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| title_sort | defining and targeting macrophage heterogeneity in the mammary gland and breast cancer |
| topic | breast cancer LYVE‐1 macrophage mammary gland TREM2 |
| url | https://doi.org/10.1002/cam4.7053 |
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