The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk
BackgroundStressful life events (SLEs) in the development of early psychosis have been little studied in low-income countries. This study examines differences in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with familial high risk for psychosis who do not meet CHR criteria...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1254993/full |
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| author | Lourdes Nieto Tecelli Domínguez-Martínez Laura Navarrete Mauricio Rosel-Vales Ricardo Saracco-Álvarez César Celada-Borja Maria Luisa Rascón-Gasca Luis Gerardo Moncayo Samperio |
| author_facet | Lourdes Nieto Tecelli Domínguez-Martínez Laura Navarrete Mauricio Rosel-Vales Ricardo Saracco-Álvarez César Celada-Borja Maria Luisa Rascón-Gasca Luis Gerardo Moncayo Samperio |
| author_sort | Lourdes Nieto |
| collection | DOAJ |
| description | BackgroundStressful life events (SLEs) in the development of early psychosis have been little studied in low-income countries. This study examines differences in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with familial high risk for psychosis who do not meet CHR criteria (non-CHR FHR). We also analyze the association between SLEs and CHR.MethodsParticipants included 43 persons with CHR and 35 with non-CHR FHR. CHR criteria were assessed with the Comprehensive Assessment of At-Risk Mental State. SLEs were assessed using the Questionnaire of Stressful Life Events.ResultsParticipants with CHR reported more SLEs associated with negative academic experiences than those in the non-CHR FHR group. Bullying (OR = 7.77, 95% CI [1.81, 33.32]) and low educational level (OR = 21.25, 95% CI [5.19, 46.90]) were the strongest predictors of CHR, while starting to live with a partner (OR = 0.26, 95% CI [0.10, 0.84]) was associated with a lower risk of CHR.ConclusionNegative school experiences increase the risk of psychosis, particularly bullying, suggesting that schools may be ideal settings for implementing individual preventive strategies to reduce risk factors and increase protective factors to improve the prognosis of those at risk of developing psychosis. In Latin America, there are multiple barriers to early intervention in psychosis. It is thus crucial to identify risk and protective factors at the onset and in the course of psychosis in order to design effective preventive interventions. |
| first_indexed | 2024-03-11T20:54:05Z |
| format | Article |
| id | doaj.art-a1bf711de21847bdb72f4a9215e802af |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-11T20:54:05Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a1bf711de21847bdb72f4a9215e802af2023-09-30T21:57:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-09-011410.3389/fpsyt.2023.12549931254993The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high riskLourdes Nieto0Tecelli Domínguez-Martínez1Laura Navarrete2Mauricio Rosel-Vales3Ricardo Saracco-Álvarez4César Celada-Borja5Maria Luisa Rascón-Gasca6Luis Gerardo Moncayo Samperio7Centro de Investigación en Salud Mental Global, Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz-UNAM, Mexico City, MexicoCentro de Investigación en Salud Mental Global, Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz-UNAM, Mexico City, MexicoDepartamento de Estudios Psicosociales en Poblaciones Específicas, Dirección de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoClínica de Esquizofrenia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoSubdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoClínica de Esquizofrenia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoDepartamento de Ciencias Sociales en Salud, Direccion de Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoDirección de Servicios Clínicos, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, MexicoBackgroundStressful life events (SLEs) in the development of early psychosis have been little studied in low-income countries. This study examines differences in the prevalence of SLEs in Mexican at clinical high risk (CHR) and those with familial high risk for psychosis who do not meet CHR criteria (non-CHR FHR). We also analyze the association between SLEs and CHR.MethodsParticipants included 43 persons with CHR and 35 with non-CHR FHR. CHR criteria were assessed with the Comprehensive Assessment of At-Risk Mental State. SLEs were assessed using the Questionnaire of Stressful Life Events.ResultsParticipants with CHR reported more SLEs associated with negative academic experiences than those in the non-CHR FHR group. Bullying (OR = 7.77, 95% CI [1.81, 33.32]) and low educational level (OR = 21.25, 95% CI [5.19, 46.90]) were the strongest predictors of CHR, while starting to live with a partner (OR = 0.26, 95% CI [0.10, 0.84]) was associated with a lower risk of CHR.ConclusionNegative school experiences increase the risk of psychosis, particularly bullying, suggesting that schools may be ideal settings for implementing individual preventive strategies to reduce risk factors and increase protective factors to improve the prognosis of those at risk of developing psychosis. In Latin America, there are multiple barriers to early intervention in psychosis. It is thus crucial to identify risk and protective factors at the onset and in the course of psychosis in order to design effective preventive interventions.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1254993/fullstressful life eventsclinical high riskfamilial high riskpsychosisbullyingdeveloping countries |
| spellingShingle | Lourdes Nieto Tecelli Domínguez-Martínez Laura Navarrete Mauricio Rosel-Vales Ricardo Saracco-Álvarez César Celada-Borja Maria Luisa Rascón-Gasca Luis Gerardo Moncayo Samperio The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk Frontiers in Psychiatry stressful life events clinical high risk familial high risk psychosis bullying developing countries |
| title | The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk |
| title_full | The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk |
| title_fullStr | The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk |
| title_full_unstemmed | The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk |
| title_short | The effect of stressful life events on the risk for psychosis: differences between Mexican at clinical and familial high risk |
| title_sort | effect of stressful life events on the risk for psychosis differences between mexican at clinical and familial high risk |
| topic | stressful life events clinical high risk familial high risk psychosis bullying developing countries |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1254993/full |
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