MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS
Contact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitizatio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/439 |
| _version_ | 1797198107322089472 |
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| author | S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov |
| author_facet | S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov |
| author_sort | S. I. Pavlova |
| collection | DOAJ |
| description | Contact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitization with 2.4-dinitrofluorobenzene. We used an adoptive transfer of contact sensitivity with different populations of splenocytes, in order to detect immunosuppressive effects of licorice (Glycyrrhizae) root flavonoids. Suppression of adoptive transfer of contact sensitivity in mice-recipients to different degree was found, when applying the flavonoids. It was revealed, that this effect depends on the type of target population interacting with flavonoids. We have also demonstrate, that licorice root flavonoids do not induce apoptosis of effector cells. |
| first_indexed | 2024-03-08T05:50:53Z |
| format | Article |
| id | doaj.art-a1bfd098f91440f4a0be3fb932b56c1b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:36Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-a1bfd098f91440f4a0be3fb932b56c1b2024-04-22T13:07:36ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0112650351010.15789/1563-0625-2010-6-503-510436MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLSS. I. Pavlova0D. Z. Albegova1A. A. Kyagova2I. G. Kozlov3ГОУ ВПО «Российский государственный медицинский университет им. Н.И. Пирогова», Москва ФГУ ФНКЦ Детской гематологии, онкологии и иммунологии Росздрава, МоскваГОУ ВПО «Российский государственный медицинский университет им. Н.И. Пирогова», МоскваГОУ ВПО «Российский государственный медицинский университет им. Н.И. Пирогова», МоскваГОУ ВПО «Российский государственный медицинский университет им. Н.И. Пирогова», Москва ФГУ ФНКЦ Детской гематологии, онкологии и иммунологии Росздрава, МоскваContact sensitivity is a classical T cell-mediated, clinically important phenomenon elicited by small molecular weight molecules (haptens) that bind to host proteins to form a complete antigen. In our model experiments, contact sensitivity was produced in CBA mice, by means of cutaneous sensitization with 2.4-dinitrofluorobenzene. We used an adoptive transfer of contact sensitivity with different populations of splenocytes, in order to detect immunosuppressive effects of licorice (Glycyrrhizae) root flavonoids. Suppression of adoptive transfer of contact sensitivity in mice-recipients to different degree was found, when applying the flavonoids. It was revealed, that this effect depends on the type of target population interacting with flavonoids. We have also demonstrate, that licorice root flavonoids do not induce apoptosis of effector cells.https://www.mimmun.ru/mimmun/article/view/439licorice root flavonoidscontact sensitivityadoptive transfer |
| spellingShingle | S. I. Pavlova D. Z. Albegova A. A. Kyagova I. G. Kozlov MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS Медицинская иммунология licorice root flavonoids contact sensitivity adoptive transfer |
| title | MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS |
| title_full | MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS |
| title_fullStr | MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS |
| title_full_unstemmed | MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS |
| title_short | MECHANISMS OF IMMUNOSUPPRESSIVE ACTION OF LICORICE ROOT FLAVONOIDS IN CONTACT SENSITIVITY IN MICE: INHIBITION OF T LYMPHOCYTE EFFECTOR FUNCTION MEDIATED BY NON- EFFECTOR CELLS |
| title_sort | mechanisms of immunosuppressive action of licorice root flavonoids in contact sensitivity in mice inhibition of t lymphocyte effector function mediated by non effector cells |
| topic | licorice root flavonoids contact sensitivity adoptive transfer |
| url | https://www.mimmun.ru/mimmun/article/view/439 |
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