The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration
The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in which stem cells reside is currently a challe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/8/5/50 |
| _version_ | 1797536664005902336 |
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| author | David H. Ramos-Rodriguez Sheila MacNeil Frederik Claeyssens Ilida Ortega Asencio |
| author_facet | David H. Ramos-Rodriguez Sheila MacNeil Frederik Claeyssens Ilida Ortega Asencio |
| author_sort | David H. Ramos-Rodriguez |
| collection | DOAJ |
| description | The recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in which stem cells reside is currently a challenge that many groups are trying to unravel. Several approaches have attempted to mimic the biological components that constitute the native stem cell niche, however, this is a very intricate environment and, although promising advances have been made recently, it becomes clear that new strategies need to be explored to ensure a better understanding of the stem cell niche behavior. The second strand in stem cell niche research focuses on the use of manufacturing techniques to build simple but functional models; these models aim to mimic the physical features of the niche environment which have also been demonstrated to play a big role in directing cell responses. This second strand has involved a more engineering approach in which a wide set of microfabrication techniques have been explored in detail. This review aims to summarize the use of these microfabrication techniques and how they have approached the challenge of mimicking the native stem cell niche. |
| first_indexed | 2024-03-10T12:03:59Z |
| format | Article |
| id | doaj.art-a1c1548d75b3441e9b3f5ff15c879753 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T12:03:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-a1c1548d75b3441e9b3f5ff15c8797532023-11-21T16:46:27ZengMDPI AGBioengineering2306-53542021-04-01855010.3390/bioengineering8050050The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue RegenerationDavid H. Ramos-Rodriguez0Sheila MacNeil1Frederik Claeyssens2Ilida Ortega Asencio3Bioengineering and Health Technologies Group, The School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UKBiomaterials and Tissue Engineering Group, Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield S3 7HQ, UKBiomaterials and Tissue Engineering Group, Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield S3 7HQ, UKBioengineering and Health Technologies Group, The School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UKThe recapitulation of the stem cell microenvironment is an emerging area of research that has grown significantly in the last 10 to 15 years. Being able to understand the underlying mechanisms that relate stem cell behavior to the physical environment in which stem cells reside is currently a challenge that many groups are trying to unravel. Several approaches have attempted to mimic the biological components that constitute the native stem cell niche, however, this is a very intricate environment and, although promising advances have been made recently, it becomes clear that new strategies need to be explored to ensure a better understanding of the stem cell niche behavior. The second strand in stem cell niche research focuses on the use of manufacturing techniques to build simple but functional models; these models aim to mimic the physical features of the niche environment which have also been demonstrated to play a big role in directing cell responses. This second strand has involved a more engineering approach in which a wide set of microfabrication techniques have been explored in detail. This review aims to summarize the use of these microfabrication techniques and how they have approached the challenge of mimicking the native stem cell niche.https://www.mdpi.com/2306-5354/8/5/50microfabricationmicrotopographiesstem cell microenvironmenttissue regeneration |
| spellingShingle | David H. Ramos-Rodriguez Sheila MacNeil Frederik Claeyssens Ilida Ortega Asencio The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration Bioengineering microfabrication microtopographies stem cell microenvironment tissue regeneration |
| title | The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration |
| title_full | The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration |
| title_fullStr | The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration |
| title_full_unstemmed | The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration |
| title_short | The Use of Microfabrication Techniques for the Design and Manufacture of Artificial Stem Cell Microenvironments for Tissue Regeneration |
| title_sort | use of microfabrication techniques for the design and manufacture of artificial stem cell microenvironments for tissue regeneration |
| topic | microfabrication microtopographies stem cell microenvironment tissue regeneration |
| url | https://www.mdpi.com/2306-5354/8/5/50 |
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