Malignant transformation of oral epithelial dysplasia in Southwest Finland
Abstract Oral epithelial dysplasia (OED) is considered a risk for oral squamous cell carcinoma (OSCC). A meta-analysis estimated a mean malignant transformation rate of 12.1% (95% CI 8.1–17.9). The main target of this study was to define how many OED patients develop OSCC in the hospital district of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-12441-9 |
| _version_ | 1811256777663053824 |
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| author | Toni T. Nevanpää Antti E. Terävä Hanna K. Laine Jaana Rautava |
| author_facet | Toni T. Nevanpää Antti E. Terävä Hanna K. Laine Jaana Rautava |
| author_sort | Toni T. Nevanpää |
| collection | DOAJ |
| description | Abstract Oral epithelial dysplasia (OED) is considered a risk for oral squamous cell carcinoma (OSCC). A meta-analysis estimated a mean malignant transformation rate of 12.1% (95% CI 8.1–17.9). The main target of this study was to define how many OED patients develop OSCC in the hospital district of Southwest Finland. A total of 571 patients diagnosed with OED were identified. Their potential subsequent diagnosis of OSCC was derived from the Finnish Cancer Registry. The risk of OSCC development in OED patients was compared with that of the general population without OED. During a mean follow-up of 5.5 (range 0.1–29.0) years 10.9% of OED patients developed OSCC. OED patients had a 44.7-fold higher risk (95% CI 34.4–56.7) of developing OSCC than the general population. The risk was at its highest within two years of OED diagnosis. OED patients in Southwest Finland have a significantly increased risk of developing OSCC relative to the general population, especially within the first two years of dysplasia diagnosis. |
| first_indexed | 2024-04-12T17:45:27Z |
| format | Article |
| id | doaj.art-a1c3fb2af4ab483d94785aaaeaec1535 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T17:45:27Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a1c3fb2af4ab483d94785aaaeaec15352022-12-22T03:22:40ZengNature PortfolioScientific Reports2045-23222022-05-011211710.1038/s41598-022-12441-9Malignant transformation of oral epithelial dysplasia in Southwest FinlandToni T. Nevanpää0Antti E. Terävä1Hanna K. Laine2Jaana Rautava3Oral Pathology and Oral Radiology, Faculty of Medicine, University of TurkuOral Pathology and Oral Radiology, Faculty of Medicine, University of TurkuOral Pathology and Oral Radiology, Faculty of Medicine, University of TurkuOral Pathology and Oral Radiology, Faculty of Medicine, University of TurkuAbstract Oral epithelial dysplasia (OED) is considered a risk for oral squamous cell carcinoma (OSCC). A meta-analysis estimated a mean malignant transformation rate of 12.1% (95% CI 8.1–17.9). The main target of this study was to define how many OED patients develop OSCC in the hospital district of Southwest Finland. A total of 571 patients diagnosed with OED were identified. Their potential subsequent diagnosis of OSCC was derived from the Finnish Cancer Registry. The risk of OSCC development in OED patients was compared with that of the general population without OED. During a mean follow-up of 5.5 (range 0.1–29.0) years 10.9% of OED patients developed OSCC. OED patients had a 44.7-fold higher risk (95% CI 34.4–56.7) of developing OSCC than the general population. The risk was at its highest within two years of OED diagnosis. OED patients in Southwest Finland have a significantly increased risk of developing OSCC relative to the general population, especially within the first two years of dysplasia diagnosis.https://doi.org/10.1038/s41598-022-12441-9 |
| spellingShingle | Toni T. Nevanpää Antti E. Terävä Hanna K. Laine Jaana Rautava Malignant transformation of oral epithelial dysplasia in Southwest Finland Scientific Reports |
| title | Malignant transformation of oral epithelial dysplasia in Southwest Finland |
| title_full | Malignant transformation of oral epithelial dysplasia in Southwest Finland |
| title_fullStr | Malignant transformation of oral epithelial dysplasia in Southwest Finland |
| title_full_unstemmed | Malignant transformation of oral epithelial dysplasia in Southwest Finland |
| title_short | Malignant transformation of oral epithelial dysplasia in Southwest Finland |
| title_sort | malignant transformation of oral epithelial dysplasia in southwest finland |
| url | https://doi.org/10.1038/s41598-022-12441-9 |
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