SARS-CoV-2 variants: Impact on biological and clinical outcome
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was first identified in December 2019, in Wuhan, China was found to be the etiological agent for a novel respiratory infection that led to a Coronavirus Induced Disease named COVID-19. The disease spread to pandemic magnitudes wit...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.995960/full |
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| author | Shakuntala Mahilkar Sachee Agrawal Sakshi Chaudhary Swapneil Parikh Subash C. Sonkar Subash C. Sonkar Dileep Kumar Verma Vidushi Chitalia Divya Mehta Bidhan Chandra Koner Bidhan Chandra Koner Neetu Vijay Jayanthi Shastri Sujatha Sunil |
| author_facet | Shakuntala Mahilkar Sachee Agrawal Sakshi Chaudhary Swapneil Parikh Subash C. Sonkar Subash C. Sonkar Dileep Kumar Verma Vidushi Chitalia Divya Mehta Bidhan Chandra Koner Bidhan Chandra Koner Neetu Vijay Jayanthi Shastri Sujatha Sunil |
| author_sort | Shakuntala Mahilkar |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was first identified in December 2019, in Wuhan, China was found to be the etiological agent for a novel respiratory infection that led to a Coronavirus Induced Disease named COVID-19. The disease spread to pandemic magnitudes within a few weeks and since then we have been dealing with several waves across the world, due to the emergence of variants and novel mutations in this RNA virus. A direct outcome of these variants apart from the spike of cases is the diverse disease presentation and difficulty in employing effective diagnostic tools apart from confusing disease outcomes. Transmissibility rates of the variants, host response, and virus evolution are some of the features found to impact COVID-19 disease management. In this review, we will discuss the emerging variants of SARS-CoV-2, notable mutations in the viral genome, the possible impact of these mutations on detection, disease presentation, and management as well as the recent findings in the mechanisms that underlie virus-host interaction. Our aim is to invigorate a scientific debate on how pathogenic potential of the new pandemic viral strains contributes toward development in the field of virology in general and COVID-19 disease in particular. |
| first_indexed | 2024-04-11T17:37:54Z |
| format | Article |
| id | doaj.art-a1c61f81b85141f48fadf3b7b02e8118 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T17:37:54Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a1c61f81b85141f48fadf3b7b02e81182022-12-22T04:11:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.995960995960SARS-CoV-2 variants: Impact on biological and clinical outcomeShakuntala Mahilkar0Sachee Agrawal1Sakshi Chaudhary2Swapneil Parikh3Subash C. Sonkar4Subash C. Sonkar5Dileep Kumar Verma6Vidushi Chitalia7Divya Mehta8Bidhan Chandra Koner9Bidhan Chandra Koner10Neetu Vijay11Jayanthi Shastri12Sujatha Sunil13Vector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, IndiaDepartment of Microbiology, Topiwala National Medical College (TNMC) and Bai Yamunabai Laxman Nair (BYL) Charitable Hospital, Mumbai, Maharashtra, IndiaVector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, IndiaMolecular Diagnostic Reference Laboratory, Kasturba Hospital for Infectious Diseases, Mumbai, Maharashtra, IndiaMultidisciplinary Research Unit, Maulana Azad Medical College and Associated Hospital, New Delhi, IndiaDelhi School of Public Health, Institute of Eminence, University of Delhi, New Delhi, IndiaVector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, IndiaMolecular Diagnostic Reference Laboratory, Kasturba Hospital for Infectious Diseases, Mumbai, Maharashtra, IndiaVector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, IndiaMultidisciplinary Research Unit, Maulana Azad Medical College and Associated Hospital, New Delhi, IndiaDepartment of Biochemistry, Maulana Azad Medical College and Associated Hospital, New Delhi, IndiaDepartment of Health Research, Ministry of Health and Family Welfare, New Delhi, IndiaDepartment of Microbiology, Topiwala National Medical College (TNMC) and Bai Yamunabai Laxman Nair (BYL) Charitable Hospital, Mumbai, Maharashtra, IndiaVector-Borne Diseases Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, IndiaThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was first identified in December 2019, in Wuhan, China was found to be the etiological agent for a novel respiratory infection that led to a Coronavirus Induced Disease named COVID-19. The disease spread to pandemic magnitudes within a few weeks and since then we have been dealing with several waves across the world, due to the emergence of variants and novel mutations in this RNA virus. A direct outcome of these variants apart from the spike of cases is the diverse disease presentation and difficulty in employing effective diagnostic tools apart from confusing disease outcomes. Transmissibility rates of the variants, host response, and virus evolution are some of the features found to impact COVID-19 disease management. In this review, we will discuss the emerging variants of SARS-CoV-2, notable mutations in the viral genome, the possible impact of these mutations on detection, disease presentation, and management as well as the recent findings in the mechanisms that underlie virus-host interaction. Our aim is to invigorate a scientific debate on how pathogenic potential of the new pandemic viral strains contributes toward development in the field of virology in general and COVID-19 disease in particular.https://www.frontiersin.org/articles/10.3389/fmed.2022.995960/fullCOVID-19SARS-CoV-2variantshost responsevirus evolutiondiagnostics |
| spellingShingle | Shakuntala Mahilkar Sachee Agrawal Sakshi Chaudhary Swapneil Parikh Subash C. Sonkar Subash C. Sonkar Dileep Kumar Verma Vidushi Chitalia Divya Mehta Bidhan Chandra Koner Bidhan Chandra Koner Neetu Vijay Jayanthi Shastri Sujatha Sunil SARS-CoV-2 variants: Impact on biological and clinical outcome Frontiers in Medicine COVID-19 SARS-CoV-2 variants host response virus evolution diagnostics |
| title | SARS-CoV-2 variants: Impact on biological and clinical outcome |
| title_full | SARS-CoV-2 variants: Impact on biological and clinical outcome |
| title_fullStr | SARS-CoV-2 variants: Impact on biological and clinical outcome |
| title_full_unstemmed | SARS-CoV-2 variants: Impact on biological and clinical outcome |
| title_short | SARS-CoV-2 variants: Impact on biological and clinical outcome |
| title_sort | sars cov 2 variants impact on biological and clinical outcome |
| topic | COVID-19 SARS-CoV-2 variants host response virus evolution diagnostics |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.995960/full |
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