(2R,3R)-2-[(4-Chlorophenyl)hydroxymethyl]cyclopentanone
The title compound, C12H13ClO2, was prepared by the direct asymmetric intermolecular aldol reaction of cyclopentanone and 4-chlorobenzaldehyde catalysed by l-tryptophan in water. The absolute molecular structure was determined to be a racemic twin with 91% (2R,3R) isomer and 9% of the (2S,3S) form....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Union of Crystallography
2009-01-01
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| Series: | Acta Crystallographica Section E |
| Online Access: | http://scripts.iucr.org/cgi-bin/paper?S160053680804261X |
| Summary: | The title compound, C12H13ClO2, was prepared by the direct asymmetric intermolecular aldol reaction of cyclopentanone and 4-chlorobenzaldehyde catalysed by l-tryptophan in water. The absolute molecular structure was determined to be a racemic twin with 91% (2R,3R) isomer and 9% of the (2S,3S) form. In the crystal structure, the molecules are connected into a one-dimensional chain along the a axis through the formation of intermolecular O—H...O hydrogen bonds. Further, non-conventional C—H...O and C—H...π contacts are observed in the structure, which consolidate the crystal packing. |
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| ISSN: | 1600-5368 |