How a PCR Sequencing Strategy Can Bring New Data to Improve the Diagnosis of Ethionamide Resistance

How a PCR Sequencing Strategy Can Bring New Data to Improve the Diagnosis of Ethionamide Resistance

Ethionamide (ETH) is a second-line antituberculosis drug. ETH resistance (ETH-R) is mainly related to the mutations of the monooxygenase-activating ETH (EthA), the ETH target (InhA), and the <i>inhA</i> promoter. Nonetheless, diagnosing ETH-R is still challenging. We assessed the strateg...

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Bibliographic Details
Main Authors: Thomas Maitre, Florence Morel, Florence Brossier, Wladimir Sougakoff, Jéremy Jaffre, Sokleaph Cheng, Nicolas Veziris, Alexandra Aubry, on behalf of the NRC-MyRMA
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Microorganisms
Subjects:
ethionamide
tuberculosis
resistance
molecular diagnosis
Online Access:https://www.mdpi.com/2076-2607/10/7/1436

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