Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study
Previous studies have found a link between tinnitus and cognitive impairment, even leading to dementia. However, the mechanisms underlying this association are not clear. The purpose of this study was to explore intrinsic network changes in tinnitus and hearing loss patients with cognitive disorders...
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MDPI AG
2022-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/8/1049 |
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| author | Wei Li Xiaobo Ma Qian Wang Xueying He Xiaoxia Qu Lirong Zhang Lanyue Chen Zhaohui Liu |
| author_facet | Wei Li Xiaobo Ma Qian Wang Xueying He Xiaoxia Qu Lirong Zhang Lanyue Chen Zhaohui Liu |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Previous studies have found a link between tinnitus and cognitive impairment, even leading to dementia. However, the mechanisms underlying this association are not clear. The purpose of this study was to explore intrinsic network changes in tinnitus and hearing loss patients with cognitive disorders. We included 17 individuals with bilateral idiopathic tinnitus, hearing loss, and cognitive impairment (PA) and 21 healthy controls. We identified resting-state networks (RSNs) and measured intra-network functional connectivity (FC) values via independent component analysis (ICA). We also evaluated correlations between RSNs and clinical characteristics. Compared with the healthy controls, the PA group showed decreased connectivity within the ventral attention network, dorsal attention network (DAN), visual network, left frontoparietal network, right frontoparietal network, sensorimotor network, and increased connectivity within the executive control network. MoCA (Montreal Cognitive Assessment) scores were negatively correlated with the FC values for left calcarine within the DAN. We identified abnormal intrinsic connectivity in several brain networks, mainly involving cognitive control, vision, sensorimotor function, and the cerebellum, in tinnitus patients with cognitive impairment. It may be possible to use the FC strength of the left calcarine within the DAN as an imaging marker to predict cognitive impairment in tinnitus patients. |
| first_indexed | 2024-03-09T11:48:38Z |
| format | Article |
| id | doaj.art-a1cda5763a32411da01790b8d2e27b6a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T11:48:38Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a1cda5763a32411da01790b8d2e27b6a2023-11-30T23:18:14ZengMDPI AGBrain Sciences2076-34252022-08-01128104910.3390/brainsci12081049Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI StudyWei Li0Xiaobo Ma1Qian Wang2Xueying He3Xiaoxia Qu4Lirong Zhang5Lanyue Chen6Zhaohui Liu7Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaDepartment of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, ChinaPrevious studies have found a link between tinnitus and cognitive impairment, even leading to dementia. However, the mechanisms underlying this association are not clear. The purpose of this study was to explore intrinsic network changes in tinnitus and hearing loss patients with cognitive disorders. We included 17 individuals with bilateral idiopathic tinnitus, hearing loss, and cognitive impairment (PA) and 21 healthy controls. We identified resting-state networks (RSNs) and measured intra-network functional connectivity (FC) values via independent component analysis (ICA). We also evaluated correlations between RSNs and clinical characteristics. Compared with the healthy controls, the PA group showed decreased connectivity within the ventral attention network, dorsal attention network (DAN), visual network, left frontoparietal network, right frontoparietal network, sensorimotor network, and increased connectivity within the executive control network. MoCA (Montreal Cognitive Assessment) scores were negatively correlated with the FC values for left calcarine within the DAN. We identified abnormal intrinsic connectivity in several brain networks, mainly involving cognitive control, vision, sensorimotor function, and the cerebellum, in tinnitus patients with cognitive impairment. It may be possible to use the FC strength of the left calcarine within the DAN as an imaging marker to predict cognitive impairment in tinnitus patients.https://www.mdpi.com/2076-3425/12/8/1049tinnitushearing losscognitive impairmentresting state functional magnetic resonance imagingindependent component analysisfunctional connectivity |
| spellingShingle | Wei Li Xiaobo Ma Qian Wang Xueying He Xiaoxia Qu Lirong Zhang Lanyue Chen Zhaohui Liu Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study Brain Sciences tinnitus hearing loss cognitive impairment resting state functional magnetic resonance imaging independent component analysis functional connectivity |
| title | Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study |
| title_full | Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study |
| title_fullStr | Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study |
| title_full_unstemmed | Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study |
| title_short | Intrinsic Network Changes in Bilateral Tinnitus Patients with Cognitive Impairment: A Resting-State Functional MRI Study |
| title_sort | intrinsic network changes in bilateral tinnitus patients with cognitive impairment a resting state functional mri study |
| topic | tinnitus hearing loss cognitive impairment resting state functional magnetic resonance imaging independent component analysis functional connectivity |
| url | https://www.mdpi.com/2076-3425/12/8/1049 |
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