The role of PET/CT in radiotherapy for nasopharyngeal carcinoma
Radiotherapy has already been developed as the standard of care for patients with nasopharyngeal carcinoma (NPC), and precision staging, target volume delineation, prognosis prediction, and post-treatment surveillance are essential in the management of NPC. Positron emission tomography/computed tomo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1017758/full |
| _version_ | 1798028761695780864 |
|---|---|
| author | Hongjia Li Ziren Kong Yongbo Xiang Rong Zheng Shaoyan Liu |
| author_facet | Hongjia Li Ziren Kong Yongbo Xiang Rong Zheng Shaoyan Liu |
| author_sort | Hongjia Li |
| collection | DOAJ |
| description | Radiotherapy has already been developed as the standard of care for patients with nasopharyngeal carcinoma (NPC), and precision staging, target volume delineation, prognosis prediction, and post-treatment surveillance are essential in the management of NPC. Positron emission tomography/computed tomography (PET/CT) is increasingly recognized as an imaging modality to guide precision radiotherapy in these areas. The feasibility and efficacy of 18F-FDG PET/CT have been confirmed in tumor diagnosis, treatment planning, prognosis, surveillance, and assessment. Coupled with the capability of revealing tumor metabolic information, 18F-FDG PET/CT is more accurate in identifying primary lesions and metastases of NPC than other conventional imaging methods including CT and MRI and shows the independently diagnostic and prognostic value for radiotherapy. However, 18F-FDG has limitations due to its physiological distribution in brain tissue and increasing uptake in post-radiation inflammation. Novel PET radiotracers including FAPI, NaF, CHO, and FLT are explored as alternatives with potential superiority for radiotherapy in NPC. In this review, we summarized the evolving role of PET/CT in the management of radiotherapy in NPC patients, aiming to facilitate precision radiotherapy from a molecular imaging aspect. |
| first_indexed | 2024-04-11T19:14:28Z |
| format | Article |
| id | doaj.art-a1cde67acf2a463b86d43833ecdfdef8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T19:14:28Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a1cde67acf2a463b86d43833ecdfdef82022-12-22T04:07:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10177581017758The role of PET/CT in radiotherapy for nasopharyngeal carcinomaHongjia Li0Ziren Kong1Yongbo Xiang2Rong Zheng3Shaoyan Liu4Department of Nuclear Medicine/PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nuclear Medicine/PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaRadiotherapy has already been developed as the standard of care for patients with nasopharyngeal carcinoma (NPC), and precision staging, target volume delineation, prognosis prediction, and post-treatment surveillance are essential in the management of NPC. Positron emission tomography/computed tomography (PET/CT) is increasingly recognized as an imaging modality to guide precision radiotherapy in these areas. The feasibility and efficacy of 18F-FDG PET/CT have been confirmed in tumor diagnosis, treatment planning, prognosis, surveillance, and assessment. Coupled with the capability of revealing tumor metabolic information, 18F-FDG PET/CT is more accurate in identifying primary lesions and metastases of NPC than other conventional imaging methods including CT and MRI and shows the independently diagnostic and prognostic value for radiotherapy. However, 18F-FDG has limitations due to its physiological distribution in brain tissue and increasing uptake in post-radiation inflammation. Novel PET radiotracers including FAPI, NaF, CHO, and FLT are explored as alternatives with potential superiority for radiotherapy in NPC. In this review, we summarized the evolving role of PET/CT in the management of radiotherapy in NPC patients, aiming to facilitate precision radiotherapy from a molecular imaging aspect.https://www.frontiersin.org/articles/10.3389/fonc.2022.1017758/fullPET/CTnasopharyngeal carcinomaradiotherapy18F-FDGnovel radiotracer |
| spellingShingle | Hongjia Li Ziren Kong Yongbo Xiang Rong Zheng Shaoyan Liu The role of PET/CT in radiotherapy for nasopharyngeal carcinoma Frontiers in Oncology PET/CT nasopharyngeal carcinoma radiotherapy 18F-FDG novel radiotracer |
| title | The role of PET/CT in radiotherapy for nasopharyngeal carcinoma |
| title_full | The role of PET/CT in radiotherapy for nasopharyngeal carcinoma |
| title_fullStr | The role of PET/CT in radiotherapy for nasopharyngeal carcinoma |
| title_full_unstemmed | The role of PET/CT in radiotherapy for nasopharyngeal carcinoma |
| title_short | The role of PET/CT in radiotherapy for nasopharyngeal carcinoma |
| title_sort | role of pet ct in radiotherapy for nasopharyngeal carcinoma |
| topic | PET/CT nasopharyngeal carcinoma radiotherapy 18F-FDG novel radiotracer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1017758/full |
| work_keys_str_mv | AT hongjiali theroleofpetctinradiotherapyfornasopharyngealcarcinoma AT zirenkong theroleofpetctinradiotherapyfornasopharyngealcarcinoma AT yongboxiang theroleofpetctinradiotherapyfornasopharyngealcarcinoma AT rongzheng theroleofpetctinradiotherapyfornasopharyngealcarcinoma AT shaoyanliu theroleofpetctinradiotherapyfornasopharyngealcarcinoma AT hongjiali roleofpetctinradiotherapyfornasopharyngealcarcinoma AT zirenkong roleofpetctinradiotherapyfornasopharyngealcarcinoma AT yongboxiang roleofpetctinradiotherapyfornasopharyngealcarcinoma AT rongzheng roleofpetctinradiotherapyfornasopharyngealcarcinoma AT shaoyanliu roleofpetctinradiotherapyfornasopharyngealcarcinoma |