Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1
Three new pimarane diterpenes, eutypellenoids A–C (1–3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1–3 possessed an uncommon tetrahydrofuran-fused pimarane dite...
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| Format: | Article |
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MDPI AG
2018-08-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/8/284 |
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| author | Hao-Bing Yu Xiao-Li Wang Wei-Heng Xu Yi-Xin Zhang Yi-Sen Qian Jian-Peng Zhang Xiao-Ling Lu Xiao-Yu Liu |
| author_facet | Hao-Bing Yu Xiao-Li Wang Wei-Heng Xu Yi-Xin Zhang Yi-Sen Qian Jian-Peng Zhang Xiao-Ling Lu Xiao-Yu Liu |
| author_sort | Hao-Bing Yu |
| collection | DOAJ |
| description | Three new pimarane diterpenes, eutypellenoids A–C (1–3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1–3 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 μg/mL, respectively. Additionally, compound 2 showed antifungal activity against Candida parapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 μg/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 μM. |
| first_indexed | 2024-04-11T11:10:55Z |
| format | Article |
| id | doaj.art-a1cf1f561b2f4d389b2337b6f8998f8d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T11:10:55Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a1cf1f561b2f4d389b2337b6f8998f8d2022-12-22T04:27:29ZengMDPI AGMarine Drugs1660-33972018-08-0116828410.3390/md16080284md16080284Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1Hao-Bing Yu0Xiao-Li Wang1Wei-Heng Xu2Yi-Xin Zhang3Yi-Sen Qian4Jian-Peng Zhang5Xiao-Ling Lu6Xiao-Yu Liu7Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaSchool of Pharmacy, Second Military Medical University, Shanghai 200433, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaSchool of Physical Sciences, University of California, Irvine, CA 92697, USADepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, and Marine Biopharmaceutical Institute, Second Military Medical University, Shanghai 200433, ChinaThree new pimarane diterpenes, eutypellenoids A–C (1–3), together with a known compound, eutypenoid C (4), were isolated from the culture extract of Eutypella sp. D-1 derived from the Arctic region. Compounds 1–3 possessed an uncommon tetrahydrofuran-fused pimarane diterpene skeleton. The structures of all compounds were determined by detailed spectroscopic analysis, electronic circular dichroism (ECD) analysis, as well as a comparison with the literature data. Antibacterial, antifungal, and cytotoxic activities of these compounds were evaluated. Compound 2 displayed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 8 and 8 μg/mL, respectively. Additionally, compound 2 showed antifungal activity against Candida parapsilosis, Candida albicans, Candida glabrata, and Candida tropicalis with MIC values of 8, 8, 16, and 32 μg/mL, respectively. Furthermore, compound 2 exhibited moderate cytotoxic activity against HCT-116 cell line with IC50 value of 3.7 μM.http://www.mdpi.com/1660-3397/16/8/284Arctic fungusEutypella sp.pimarane diterpenebioactivity |
| spellingShingle | Hao-Bing Yu Xiao-Li Wang Wei-Heng Xu Yi-Xin Zhang Yi-Sen Qian Jian-Peng Zhang Xiao-Ling Lu Xiao-Yu Liu Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 Marine Drugs Arctic fungus Eutypella sp. pimarane diterpene bioactivity |
| title | Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 |
| title_full | Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 |
| title_fullStr | Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 |
| title_full_unstemmed | Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 |
| title_short | Eutypellenoids A–C, New Pimarane Diterpenes from the Arctic Fungus Eutypella sp. D-1 |
| title_sort | eutypellenoids a c new pimarane diterpenes from the arctic fungus eutypella sp d 1 |
| topic | Arctic fungus Eutypella sp. pimarane diterpene bioactivity |
| url | http://www.mdpi.com/1660-3397/16/8/284 |
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