Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a signific...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/11/1181 |
| _version_ | 1797508813907034112 |
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| author | Eirini Filidou George Kolios |
| author_facet | Eirini Filidou George Kolios |
| author_sort | Eirini Filidou |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a significant decrease in the microbiome diversity of patients with IBD. Although the question of whether microbiota dysbiosis is a causal factor or the result of chronic inflammation remains unanswered, one fact is clear; active inflammation in IBD results in the disruption of the mucus layer structure, barrier function, and also, colonization sites. Recently, many studies on IBD have been focusing on the interplay between mucosal and luminal microbiota, underlining their possible beneficial effect on mucosal healing. Regarding this notion, it has now been shown that specific probiotic strains, when administrated, lead to significantly decreased inflammation, amelioration of colitis, and improved mucosal healing. Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate quantity. The aim of this review was to present and discuss the current findings on the role of gut microbiota and their metabolites in intestinal wound healing and the effects of probiotics on intestinal mucosal wound closure. |
| first_indexed | 2024-03-10T05:10:12Z |
| format | Article |
| id | doaj.art-a1d038f3866f4012a2647d05beeb77a9 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:10:12Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-a1d038f3866f4012a2647d05beeb77a92023-11-23T00:56:28ZengMDPI AGPharmaceuticals1424-82472021-11-011411118110.3390/ph14111181Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?Eirini Filidou0George Kolios1Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, GreeceLaboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, GreeceInflammatory bowel disease (IBD), Crohn’s disease, and ulcerative colitis are characterized by chronic and relapsing inflammation, while their pathogenesis remains mostly unelucidated. Gut commensal microbiota seem to be one of the various implicated factors, as several studies have shown a significant decrease in the microbiome diversity of patients with IBD. Although the question of whether microbiota dysbiosis is a causal factor or the result of chronic inflammation remains unanswered, one fact is clear; active inflammation in IBD results in the disruption of the mucus layer structure, barrier function, and also, colonization sites. Recently, many studies on IBD have been focusing on the interplay between mucosal and luminal microbiota, underlining their possible beneficial effect on mucosal healing. Regarding this notion, it has now been shown that specific probiotic strains, when administrated, lead to significantly decreased inflammation, amelioration of colitis, and improved mucosal healing. Probiotics are live microorganisms exerting beneficial effects on the host’s health when administered in adequate quantity. The aim of this review was to present and discuss the current findings on the role of gut microbiota and their metabolites in intestinal wound healing and the effects of probiotics on intestinal mucosal wound closure.https://www.mdpi.com/1424-8247/14/11/1181probioticsintestinal wound healinggut microbiotamucosal healinginflammatory bowel disease |
| spellingShingle | Eirini Filidou George Kolios Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? Pharmaceuticals probiotics intestinal wound healing gut microbiota mucosal healing inflammatory bowel disease |
| title | Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? |
| title_full | Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? |
| title_fullStr | Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? |
| title_full_unstemmed | Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? |
| title_short | Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend? |
| title_sort | probiotics in intestinal mucosal healing a new therapy or an old friend |
| topic | probiotics intestinal wound healing gut microbiota mucosal healing inflammatory bowel disease |
| url | https://www.mdpi.com/1424-8247/14/11/1181 |
| work_keys_str_mv | AT eirinifilidou probioticsinintestinalmucosalhealinganewtherapyoranoldfriend AT georgekolios probioticsinintestinalmucosalhealinganewtherapyoranoldfriend |