8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer.
BACKGROUND: Association studies have identified low penetrance alleles that participate to the risk of cancer development. The 8q24 chromosomal region contains several such loci involved in various cancers that have been recently studied for their propensity to influence the clinical outcome of pros...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3362533?pdf=render |
| _version_ | 1818525844107165696 |
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| author | François Bertucci Arnaud Lagarde Anthony Ferrari Pascal Finetti Emmanuelle Charafe-Jauffret Steven Van Laere José Adelaide Patrice Viens Gilles Thomas Daniel Birnbaum Sylviane Olschwang |
| author_facet | François Bertucci Arnaud Lagarde Anthony Ferrari Pascal Finetti Emmanuelle Charafe-Jauffret Steven Van Laere José Adelaide Patrice Viens Gilles Thomas Daniel Birnbaum Sylviane Olschwang |
| author_sort | François Bertucci |
| collection | DOAJ |
| description | BACKGROUND: Association studies have identified low penetrance alleles that participate to the risk of cancer development. The 8q24 chromosomal region contains several such loci involved in various cancers that have been recently studied for their propensity to influence the clinical outcome of prostate cancer. We investigated here two 8q24 breast and colon cancer risk alleles in the close vicinity of the MYC gene for their role in the occurrence of distant metastases. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective series of 449 patients affected with breast or colon adenocarcinoma was genotyped for the rs13281615 and/or rs6983267 SNPs. Statistical analyses were done using the survival package v2.30 in the R software v2.9.1. The two SNPs did not influence the development of distant metastases of colon cancer; rs6983267 showed a mild effect on breast cancer. However, this effect was greatly emphasized when considering inflammatory breast cancer (IBC) solely. Replicated on a larger and independent series of IBC the contribution of the genotype to the metastatic risk of IBC was found an independent predictor of outcome (p = 2e-4; OR 8.3, CI95:2.6-33). CONCLUSIONS/SIGNIFICANCE: Our study shows first that the monitoring of this specific germline variation may add a substantial tool for IBC prognostication, an aggressive disease that evolves towards distant metastases much more frequently than non-IBC and for which no reliable prognostic factor is available in medical practice. Second, it more generally suggests that risk alleles, while associated with low susceptibility, could correlate with a high risk of metastasis. |
| first_indexed | 2024-12-11T06:14:45Z |
| format | Article |
| id | doaj.art-a1d1bc02cb124656b5e3f27997151439 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T06:14:45Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a1d1bc02cb124656b5e3f279971514392022-12-22T01:18:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3794310.1371/journal.pone.00379438q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer.François BertucciArnaud LagardeAnthony FerrariPascal FinettiEmmanuelle Charafe-JauffretSteven Van LaereJosé AdelaidePatrice ViensGilles ThomasDaniel BirnbaumSylviane OlschwangBACKGROUND: Association studies have identified low penetrance alleles that participate to the risk of cancer development. The 8q24 chromosomal region contains several such loci involved in various cancers that have been recently studied for their propensity to influence the clinical outcome of prostate cancer. We investigated here two 8q24 breast and colon cancer risk alleles in the close vicinity of the MYC gene for their role in the occurrence of distant metastases. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective series of 449 patients affected with breast or colon adenocarcinoma was genotyped for the rs13281615 and/or rs6983267 SNPs. Statistical analyses were done using the survival package v2.30 in the R software v2.9.1. The two SNPs did not influence the development of distant metastases of colon cancer; rs6983267 showed a mild effect on breast cancer. However, this effect was greatly emphasized when considering inflammatory breast cancer (IBC) solely. Replicated on a larger and independent series of IBC the contribution of the genotype to the metastatic risk of IBC was found an independent predictor of outcome (p = 2e-4; OR 8.3, CI95:2.6-33). CONCLUSIONS/SIGNIFICANCE: Our study shows first that the monitoring of this specific germline variation may add a substantial tool for IBC prognostication, an aggressive disease that evolves towards distant metastases much more frequently than non-IBC and for which no reliable prognostic factor is available in medical practice. Second, it more generally suggests that risk alleles, while associated with low susceptibility, could correlate with a high risk of metastasis.http://europepmc.org/articles/PMC3362533?pdf=render |
| spellingShingle | François Bertucci Arnaud Lagarde Anthony Ferrari Pascal Finetti Emmanuelle Charafe-Jauffret Steven Van Laere José Adelaide Patrice Viens Gilles Thomas Daniel Birnbaum Sylviane Olschwang 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. PLoS ONE |
| title | 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. |
| title_full | 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. |
| title_fullStr | 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. |
| title_full_unstemmed | 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. |
| title_short | 8q24 Cancer risk allele associated with major metastatic risk in inflammatory breast cancer. |
| title_sort | 8q24 cancer risk allele associated with major metastatic risk in inflammatory breast cancer |
| url | http://europepmc.org/articles/PMC3362533?pdf=render |
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