Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

Abstract Frontotemporal dementia (FTD) is amongst the most prevalent early onset dementias and even though it is clinically, pathologically and genetically heterogeneous, a crucial involvement of metabolic perturbations in FTD pathology is being recognized. However, changes in metabolism at the cell...

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Bibliographic Details
Main Authors: Blanca I. Aldana, Yu Zhang, Pia Jensen, Abinaya Chandrasekaran, Sofie K. Christensen, Troels T. Nielsen, Jørgen E. Nielsen, Poul Hyttel, Martin R. Larsen, Helle S. Waagepetersen, Kristine K. Freude
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Molecular Brain
Subjects:
FTD3
CHMP2B
iPSC-derived neuron
Glucose metabolism
Glutamate
Glutamine
Online Access:http://link.springer.com/article/10.1186/s13041-020-00658-6

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http://link.springer.com/article/10.1186/s13041-020-00658-6

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