Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature
Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-02-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709621997248 |
| _version_ | 1818847537956651008 |
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| author | Donya Farmand MPH Michael C. Valdez MD Leila Moosavi MD Everardo Cobos MD |
| author_facet | Donya Farmand MPH Michael C. Valdez MD Leila Moosavi MD Everardo Cobos MD |
| author_sort | Donya Farmand MPH |
| collection | DOAJ |
| description | Locus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness. |
| first_indexed | 2024-12-19T06:03:02Z |
| format | Article |
| id | doaj.art-a1d2faa5914a44b49b9d755b46c659ce |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-19T06:03:02Z |
| publishDate | 2021-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-a1d2faa5914a44b49b9d755b46c659ce2022-12-21T20:33:15ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962021-02-01910.1177/2324709621997248Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of LiteratureDonya Farmand MPH0Michael C. Valdez MD1Leila Moosavi MD2Everardo Cobos MD3Department of Medicine, Kern Medical-UCLA, Bakersfield, CA, USADepartment of Medicine, Kern Medical-UCLA, Bakersfield, CA, USADepartment of Medicine, Kern Medical-UCLA, Bakersfield, CA, USADepartment of Medicine, Kern Medical-UCLA, Bakersfield, CA, USALocus minoris resistentiae refers to a region of decreased resistance within the body. This occurs from changes to the microenvironment secondary to previous trauma and results in increased vulnerability. As a result, infection, inflammatory processes, and malignancy may localize to this area. In this article, we describe 2 unique cases of malignancy, primary prostate carcinoma and serous carcinoma of the ovary, both of which disseminated to sites of prior trauma. We review the available literature, discuss proposed pathophysiology, and highlight the need for further investigations along with increased clinician awareness.https://doi.org/10.1177/2324709621997248 |
| spellingShingle | Donya Farmand MPH Michael C. Valdez MD Leila Moosavi MD Everardo Cobos MD Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature Journal of Investigative Medicine High Impact Case Reports |
| title | Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature |
| title_full | Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature |
| title_fullStr | Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature |
| title_full_unstemmed | Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature |
| title_short | Locus Minoris Resistentiae: Two Cases of Malignant Metastasis and Review of Literature |
| title_sort | locus minoris resistentiae two cases of malignant metastasis and review of literature |
| url | https://doi.org/10.1177/2324709621997248 |
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