DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster
Abstract Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic muta...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300431&lng=en&tlng=en |
| _version_ | 1819081009860182016 |
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| author | Robson Alves da Silva Rafael Rodrigues Dihl Lucas Pinheiro Dias Maiane Papke Costa Bianca Regina Ribas de Abreu Kênya Silva Cunha Mauricio Lehmann |
| author_facet | Robson Alves da Silva Rafael Rodrigues Dihl Lucas Pinheiro Dias Maiane Papke Costa Bianca Regina Ribas de Abreu Kênya Silva Cunha Mauricio Lehmann |
| author_sort | Robson Alves da Silva |
| collection | DOAJ |
| description | Abstract Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages. |
| first_indexed | 2024-12-21T19:53:58Z |
| format | Article |
| id | doaj.art-a1d33f88e5594928a1390f748afc39a5 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-21T19:53:58Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-a1d33f88e5594928a1390f748afc39a52022-12-21T18:52:09ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-468539343144110.1590/1678-4685-GMB-2015-0129S1415-47572016000300431DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogasterRobson Alves da SilvaRafael Rodrigues DihlLucas Pinheiro DiasMaiane Papke CostaBianca Regina Ribas de AbreuKênya Silva CunhaMauricio LehmannAbstract Fruits and derivatives, such as juices, are complex mixtures of chemicals, some of which may have mutagenic and/or carcinogenic potential, while others may have antimutagenic and/or anticancer activities. The modulating effects of honey-sweetened cashew apple nectar (HSCAN), on somatic mutation and recombination induced by ethyl methanesulfonate (EMS) and mitomycin C (MMC) were evaluated with the wing spot test in Drosophila melanogaster using co- and post-treatment protocols. Additionally, the antimutagenic activity of two HSCAN components, cashew apple pulp and honey, in MMC-induced DNA damage was also investigated. HSCAN reduced the mutagenic activity of both EMS and MMC in the co-treatment protocol, but had a co-mutagenic effect when post-administered. Similar results were also observed with honey on MMC mutagenic activity. Cashew apple pulp was effective in exerting protective or enhancing effects on the MMC mutagenicity, depending on the administration protocol and concentration used. Overall, these results indicate that HSCAN, cashew apple and honey seem capable of modulating not only the events that precede the induced DNA damages, but also the Drosophila DNA repair processes involved in the correction of EMS and MMC-induced damages.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300431&lng=en&tlng=enantimutagenicitycashew appleDrosophila melanogasterhoneysomatic cells |
| spellingShingle | Robson Alves da Silva Rafael Rodrigues Dihl Lucas Pinheiro Dias Maiane Papke Costa Bianca Regina Ribas de Abreu Kênya Silva Cunha Mauricio Lehmann DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster Genetics and Molecular Biology antimutagenicity cashew apple Drosophila melanogaster honey somatic cells |
| title | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster |
| title_full | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster |
| title_fullStr | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster |
| title_full_unstemmed | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster |
| title_short | DNA damage protective effect of honey-sweetened cashew apple nectar in Drosophila melanogaster |
| title_sort | dna damage protective effect of honey sweetened cashew apple nectar in drosophila melanogaster |
| topic | antimutagenicity cashew apple Drosophila melanogaster honey somatic cells |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300431&lng=en&tlng=en |
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