Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface
Osteoarthritis is a debilitating disease that results in pain and joint stiffness. Currently, steroidal and nonsteroidal anti-inflammatory drugs and supplements aimed at restoring lubrication to the affected joint are the most successful with respect to improving patient comfort. Due to the success...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Current Research in Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590262820300046 |
| _version_ | 1819278951529316352 |
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| author | Celina Twitchell Tanaya Walimbe Julie C. Liu Alyssa Panitch |
| author_facet | Celina Twitchell Tanaya Walimbe Julie C. Liu Alyssa Panitch |
| author_sort | Celina Twitchell |
| collection | DOAJ |
| description | Osteoarthritis is a debilitating disease that results in pain and joint stiffness. Currently, steroidal and nonsteroidal anti-inflammatory drugs and supplements aimed at restoring lubrication to the affected joint are the most successful with respect to improving patient comfort. Due to the success in lubricating therapies, there exists a keen interest to develop better therapies that mimic how lubrication occurs naturally in the joint. Here we describe the results obtained using a chondroitin sulfate chain to which is conjugated peptides that bind to either hyaluronic acid (found in high concentrations in the synovial fluid) or collagen type II (present on the cartilage surface). Our study investigates the effect of binding to the cartilage surface and interacting with hyaluronic acid on lubrication at the cartilage surface. The results described here suggest that binding to the cartilage surface is critical to supporting lubrication and did not require the addition of hyaluronic acid to reduce friction. |
| first_indexed | 2024-12-24T00:20:10Z |
| format | Article |
| id | doaj.art-a1d379aa002a42e289ca9a22238fd3e9 |
| institution | Directory Open Access Journal |
| issn | 2590-2628 |
| language | English |
| last_indexed | 2024-12-24T00:20:10Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Biotechnology |
| spelling | doaj.art-a1d379aa002a42e289ca9a22238fd3e92022-12-21T17:24:37ZengElsevierCurrent Research in Biotechnology2590-26282020-11-0121621Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surfaceCelina Twitchell0Tanaya Walimbe1Julie C. Liu2Alyssa Panitch3Weldon School of Biomedical Engineering, 206, S. Martin Jischke Dr, Purdue University, West Lafayette, IN, United States of AmericaDepartment of Biomedical Engineering, 451 E, Health Sciences Dr, University of California, Davis, Davis, CA, United States of AmericaDavidson School of Chemical Engineering, 480 West Stadium Ave., Purdue University, West Lafayette, IN, United States of AmericaDepartment of Biomedical Engineering, 451 E, Health Sciences Dr, University of California, Davis, Davis, CA, United States of America; Corresponding author.Osteoarthritis is a debilitating disease that results in pain and joint stiffness. Currently, steroidal and nonsteroidal anti-inflammatory drugs and supplements aimed at restoring lubrication to the affected joint are the most successful with respect to improving patient comfort. Due to the success in lubricating therapies, there exists a keen interest to develop better therapies that mimic how lubrication occurs naturally in the joint. Here we describe the results obtained using a chondroitin sulfate chain to which is conjugated peptides that bind to either hyaluronic acid (found in high concentrations in the synovial fluid) or collagen type II (present on the cartilage surface). Our study investigates the effect of binding to the cartilage surface and interacting with hyaluronic acid on lubrication at the cartilage surface. The results described here suggest that binding to the cartilage surface is critical to supporting lubrication and did not require the addition of hyaluronic acid to reduce friction.http://www.sciencedirect.com/science/article/pii/S2590262820300046LubricationCartilageOsteoarthritisFrictionLubricinHyaluronic acid |
| spellingShingle | Celina Twitchell Tanaya Walimbe Julie C. Liu Alyssa Panitch Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface Current Research in Biotechnology Lubrication Cartilage Osteoarthritis Friction Lubricin Hyaluronic acid |
| title | Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| title_full | Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| title_fullStr | Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| title_full_unstemmed | Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| title_short | Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| title_sort | peptide modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface |
| topic | Lubrication Cartilage Osteoarthritis Friction Lubricin Hyaluronic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2590262820300046 |
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