A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma
Abstract Docetaxel is a cytotoxic taxane frequently used to treat patients with various cancers, including non‐small cell lung cancer (NSCLC). Docetaxel is known to cause acute myalgias, arthralgias, and neuropathy, but there have been few published case reports of myositis. Here, we describe a rare...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14480 |
| _version_ | 1818163769739575296 |
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| author | Akane Ishida Ayumi Ushio Masao Hashimoto Satoru Ishii Go Naka Motoyasu Iikura Shinyu Izumi Masayuki Hojo Haruhito Sugiyama |
| author_facet | Akane Ishida Ayumi Ushio Masao Hashimoto Satoru Ishii Go Naka Motoyasu Iikura Shinyu Izumi Masayuki Hojo Haruhito Sugiyama |
| author_sort | Akane Ishida |
| collection | DOAJ |
| description | Abstract Docetaxel is a cytotoxic taxane frequently used to treat patients with various cancers, including non‐small cell lung cancer (NSCLC). Docetaxel is known to cause acute myalgias, arthralgias, and neuropathy, but there have been few published case reports of myositis. Here, we describe a rare case of docetaxel‐induced myositis diagnosed based on laboratory data, thigh magnetic resonance imaging (MRI), and electromyography (EEG). A 66‐year‐old male was admitted for thigh pain and fatigue that onset 1 week prior. He had been diagnosed with stage IVA (cT4N0M1a) NSCLC 3 years ago and had been started on docetaxel (60 mg/m2 intravenously every 3 weeks; fourth‐line chemotherapy) 1 month earlier. After the second cycle, he developed both thigh pain and fatigue. On admission, his creatinine phosphokinase (CPK) level was elevated, thigh MRI revealed diffuse muscle edema, and EEG showed myogenic changes. We found no plausible cause for myositis except docetaxel. He was diagnosed with myositis and treated with oral prednisolone. His symptoms were relieved and the CPK level declined. Although rare, this case indicates that clinicians should consider the possibility of myositis as a complication in patients on docetaxel. |
| first_indexed | 2024-12-11T16:54:50Z |
| format | Article |
| id | doaj.art-a1d3d3ec82a248158b23efe94d77ce0f |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-11T16:54:50Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-a1d3d3ec82a248158b23efe94d77ce0f2022-12-22T00:58:00ZengWileyThoracic Cancer1759-77061759-77142022-07-0113142075207710.1111/1759-7714.14480A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinomaAkane Ishida0Ayumi Ushio1Masao Hashimoto2Satoru Ishii3Go Naka4Motoyasu Iikura5Shinyu Izumi6Masayuki Hojo7Haruhito Sugiyama8Department of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanDepartment of Respiratory Medicine National Center for Global Health and Medicine Tokyo JapanAbstract Docetaxel is a cytotoxic taxane frequently used to treat patients with various cancers, including non‐small cell lung cancer (NSCLC). Docetaxel is known to cause acute myalgias, arthralgias, and neuropathy, but there have been few published case reports of myositis. Here, we describe a rare case of docetaxel‐induced myositis diagnosed based on laboratory data, thigh magnetic resonance imaging (MRI), and electromyography (EEG). A 66‐year‐old male was admitted for thigh pain and fatigue that onset 1 week prior. He had been diagnosed with stage IVA (cT4N0M1a) NSCLC 3 years ago and had been started on docetaxel (60 mg/m2 intravenously every 3 weeks; fourth‐line chemotherapy) 1 month earlier. After the second cycle, he developed both thigh pain and fatigue. On admission, his creatinine phosphokinase (CPK) level was elevated, thigh MRI revealed diffuse muscle edema, and EEG showed myogenic changes. We found no plausible cause for myositis except docetaxel. He was diagnosed with myositis and treated with oral prednisolone. His symptoms were relieved and the CPK level declined. Although rare, this case indicates that clinicians should consider the possibility of myositis as a complication in patients on docetaxel.https://doi.org/10.1111/1759-7714.14480docetaxellung cancermyositis |
| spellingShingle | Akane Ishida Ayumi Ushio Masao Hashimoto Satoru Ishii Go Naka Motoyasu Iikura Shinyu Izumi Masayuki Hojo Haruhito Sugiyama A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma Thoracic Cancer docetaxel lung cancer myositis |
| title | A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma |
| title_full | A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma |
| title_fullStr | A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma |
| title_full_unstemmed | A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma |
| title_short | A rare case of docetaxel‐induced myositis in a patient with a lung adenocarcinoma |
| title_sort | rare case of docetaxel induced myositis in a patient with a lung adenocarcinoma |
| topic | docetaxel lung cancer myositis |
| url | https://doi.org/10.1111/1759-7714.14480 |
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