Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis
Introduction: IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2011-01-01
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| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://ijorl.mums.ac.ir/pdf_623_c941af1cc1254b2ae1ca213e399e21e0.html |
| _version_ | 1811306144830849024 |
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| author | Bijan Khademi Seyed Hossein Dastgheib Eskandar Kamali-Sarvestani |
| author_facet | Bijan Khademi Seyed Hossein Dastgheib Eskandar Kamali-Sarvestani |
| author_sort | Bijan Khademi |
| collection | DOAJ |
| description | Introduction:
IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2 +1208 C/T genes polymorphisms and susceptibility to CRS and NP.
Materials and Methods:
Two hundred and forty fiveCRS patients and 204 healthy controls were included in this study. CRS patients were categorized by the existence or absence of NP. IL-8 promoter-251 A/T and CXCR2 +1208 C/T gene polymorphisms were genotyped via the allele specific PCR (AS-PCR) method.
Results:
While no remarkable difference was demonstrated between patients and controls for both CXCR2 +1208 C/T and IL-8 -251 A/T polymorphisms, a significant increase in IL-8-251 AA genotype was detected in CRS patients with NP compared to those without it (29.3% and 16.2%, respectively; P=0.03). Interestingly, this association got far stronger when only non-asthmatic CRS patients were taken into consideration (P=0.001).
Conclusion:
The results of the present study indicate that the inheritance of IL-8-251 Aallele is associated significantly with NP development in CRS patients. Therefore, NP formation might be a result of the exposure to an intense inflammatory environment, which is more likely in genetically susceptible CRS patients. |
| first_indexed | 2024-04-13T08:40:16Z |
| format | Article |
| id | doaj.art-a1d3de6c999e49858f835036e089d7de |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-04-13T08:40:16Z |
| publishDate | 2011-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-a1d3de6c999e49858f835036e089d7de2022-12-22T02:53:57ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2011-01-0123622936623Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic RhinosinusitisBijan Khademi0Seyed Hossein Dastgheib1Eskandar Kamali-Sarvestani2Department of otorhinolaryngology, Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz,IranDepartment of otorhinolaryngology, Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, IranDepartment of immunology, Shiraz University of Medical Sciences, Shiraz, IranIntroduction: IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2 +1208 C/T genes polymorphisms and susceptibility to CRS and NP. Materials and Methods: Two hundred and forty fiveCRS patients and 204 healthy controls were included in this study. CRS patients were categorized by the existence or absence of NP. IL-8 promoter-251 A/T and CXCR2 +1208 C/T gene polymorphisms were genotyped via the allele specific PCR (AS-PCR) method. Results: While no remarkable difference was demonstrated between patients and controls for both CXCR2 +1208 C/T and IL-8 -251 A/T polymorphisms, a significant increase in IL-8-251 AA genotype was detected in CRS patients with NP compared to those without it (29.3% and 16.2%, respectively; P=0.03). Interestingly, this association got far stronger when only non-asthmatic CRS patients were taken into consideration (P=0.001). Conclusion: The results of the present study indicate that the inheritance of IL-8-251 Aallele is associated significantly with NP development in CRS patients. Therefore, NP formation might be a result of the exposure to an intense inflammatory environment, which is more likely in genetically susceptible CRS patients.http://ijorl.mums.ac.ir/pdf_623_c941af1cc1254b2ae1ca213e399e21e0.htmlChronic rhinosinusitisCXCR2InterleukinL-8Nasal polyposisPolymorphism |
| spellingShingle | Bijan Khademi Seyed Hossein Dastgheib Eskandar Kamali-Sarvestani Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis Iranian Journal of Otorhinolaryngology Chronic rhinosinusitis CXCR2 InterleukinL-8 Nasal polyposis Polymorphism |
| title | Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis |
| title_full | Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis |
| title_fullStr | Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis |
| title_full_unstemmed | Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis |
| title_short | Interleukin-8-251 A/T and CXCR2 +1208 C/T Genes Polymorphisms in Chronic Rhinosinusitis |
| title_sort | interleukin 8 251 a t and cxcr2 1208 c t genes polymorphisms in chronic rhinosinusitis |
| topic | Chronic rhinosinusitis CXCR2 InterleukinL-8 Nasal polyposis Polymorphism |
| url | http://ijorl.mums.ac.ir/pdf_623_c941af1cc1254b2ae1ca213e399e21e0.html |
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