Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells
Microglia play important physiological roles in central nervous system (CNS) homeostasis and in the pathogenesis of inflammatory brain diseases. Inflammation stimulates microglia to secrete cytokines and chemokines that guide immune cells to sites of injury/inflammation. Neuroinflammation is also st...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/8/3/51 |
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| author | Chiara Porro Antonia Cianciulli Teresa Trotta Dario Domenico Lofrumento Maria Antonietta Panaro |
| author_facet | Chiara Porro Antonia Cianciulli Teresa Trotta Dario Domenico Lofrumento Maria Antonietta Panaro |
| author_sort | Chiara Porro |
| collection | DOAJ |
| description | Microglia play important physiological roles in central nervous system (CNS) homeostasis and in the pathogenesis of inflammatory brain diseases. Inflammation stimulates microglia to secrete cytokines and chemokines that guide immune cells to sites of injury/inflammation. Neuroinflammation is also strongly implicated in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, for which nutritional intervention could represent a benefit due to a lack of clinically efficacious drugs. To this end, the anti-inflammatory mechanisms of several phytochemicals, including curcumin, have been extensively studied. The present experiments show that the administration of curcumin is able to increase the production of the anti-inflammatory cytokines, IL-4 and IL-10, in murine BV-2 microglial cells treated with lipopolysaccharide (LPS). Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced. Taken together, these results provide evidence that curcumin is able to regulate neuroinflammatory reactions by eliciting anti-inflammatory responses in microglia through JAK/STAT/SOCS signaling pathway modulation. |
| first_indexed | 2024-03-12T19:27:49Z |
| format | Article |
| id | doaj.art-a1d567f0d7a9462e92c6bd5171186899 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T19:27:49Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a1d567f0d7a9462e92c6bd51711868992023-08-02T04:47:44ZengMDPI AGBiology2079-77372019-06-01835110.3390/biology8030051biology8030051Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial CellsChiara Porro0Antonia Cianciulli1Teresa Trotta2Dario Domenico Lofrumento3Maria Antonietta Panaro4Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, 73100 Lecce, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70126 Bari, ItalyMicroglia play important physiological roles in central nervous system (CNS) homeostasis and in the pathogenesis of inflammatory brain diseases. Inflammation stimulates microglia to secrete cytokines and chemokines that guide immune cells to sites of injury/inflammation. Neuroinflammation is also strongly implicated in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, for which nutritional intervention could represent a benefit due to a lack of clinically efficacious drugs. To this end, the anti-inflammatory mechanisms of several phytochemicals, including curcumin, have been extensively studied. The present experiments show that the administration of curcumin is able to increase the production of the anti-inflammatory cytokines, IL-4 and IL-10, in murine BV-2 microglial cells treated with lipopolysaccharide (LPS). Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced. Taken together, these results provide evidence that curcumin is able to regulate neuroinflammatory reactions by eliciting anti-inflammatory responses in microglia through JAK/STAT/SOCS signaling pathway modulation.https://www.mdpi.com/2079-7737/8/3/51microgliaSOCS-1curcuminJAK/STATIL-4IL-10 |
| spellingShingle | Chiara Porro Antonia Cianciulli Teresa Trotta Dario Domenico Lofrumento Maria Antonietta Panaro Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells Biology microglia SOCS-1 curcumin JAK/STAT IL-4 IL-10 |
| title | Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells |
| title_full | Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells |
| title_fullStr | Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells |
| title_full_unstemmed | Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells |
| title_short | Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells |
| title_sort | curcumin regulates anti inflammatory responses by jak stat socs signaling pathway in bv 2 microglial cells |
| topic | microglia SOCS-1 curcumin JAK/STAT IL-4 IL-10 |
| url | https://www.mdpi.com/2079-7737/8/3/51 |
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