Histopathologic and immunohistochemical features of Hashimoto thyroiditis
Background: Intrathyroid lymphoid tissue is accrued in Hashimoto thyroiditis (HT). Histologically, this acquired lymphoid tissue bears a close resemblance to mucosa-associated lymphoid tissue (MALT) and can evolve to lymphoma. Aim: To demonstrate the morphological, and immunohistochemical profiles o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=464;epage=471;aulast=Amani |
| _version_ | 1811217162439753728 |
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| author | H Kazem Amani |
| author_facet | H Kazem Amani |
| author_sort | H Kazem Amani |
| collection | DOAJ |
| description | Background: Intrathyroid lymphoid tissue is accrued in Hashimoto thyroiditis (HT). Histologically, this acquired lymphoid tissue bears a close resemblance to mucosa-associated lymphoid tissue (MALT) and can evolve to lymphoma. Aim: To demonstrate the morphological, and immunohistochemical profiles of Hashimoto thyroiditis and to ascertain the importance of light chain restriction in distinguishing HT with extensive lymphoplasmacytoid infiltrate from MALT lymphoma. Materials and Methods: We studied histopathologically and immunohistochemically (CD20, CD3, Igk, Igl and cytokeratin) 30 cases of HT for evaluation of the lymphoid infiltrate and the presence of lymphoepithelial lesions (LELs). Distinguishing between early thyroid lymphoma and HT was evaluated by light chain restriction. These findings were compared with two cases of primary thyroid lymphoma. Results: The histopathological findings were characteristic of HT. Immunohistochemistry confirmed inconspicuous, rare B-cell LELs as well as a prominent T-lymphocyte population. Testing for light chain restriction showed polyclonal population of plasma cells. The cases of MALT lymphoma had distinct destructive lymphoepithelial lesions, B-cell immunophenotyping and showed kappa light chain restriction in the plasmacytoid population. Conclusions: Hashimoto thyroiditis differs both histopathologically and immunohistochemically from thyroid lymphoma. In suspicious cases, immunohistochemistry could be helpful in reaching a definitive diagnosis. |
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| id | doaj.art-a1d9543680af4496aad8879a8c2bed7e |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-12T06:49:17Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-a1d9543680af4496aad8879a8c2bed7e2022-12-22T03:43:25ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-0154346447110.4103/0377-4929.85076Histopathologic and immunohistochemical features of Hashimoto thyroiditisH Kazem AmaniBackground: Intrathyroid lymphoid tissue is accrued in Hashimoto thyroiditis (HT). Histologically, this acquired lymphoid tissue bears a close resemblance to mucosa-associated lymphoid tissue (MALT) and can evolve to lymphoma. Aim: To demonstrate the morphological, and immunohistochemical profiles of Hashimoto thyroiditis and to ascertain the importance of light chain restriction in distinguishing HT with extensive lymphoplasmacytoid infiltrate from MALT lymphoma. Materials and Methods: We studied histopathologically and immunohistochemically (CD20, CD3, Igk, Igl and cytokeratin) 30 cases of HT for evaluation of the lymphoid infiltrate and the presence of lymphoepithelial lesions (LELs). Distinguishing between early thyroid lymphoma and HT was evaluated by light chain restriction. These findings were compared with two cases of primary thyroid lymphoma. Results: The histopathological findings were characteristic of HT. Immunohistochemistry confirmed inconspicuous, rare B-cell LELs as well as a prominent T-lymphocyte population. Testing for light chain restriction showed polyclonal population of plasma cells. The cases of MALT lymphoma had distinct destructive lymphoepithelial lesions, B-cell immunophenotyping and showed kappa light chain restriction in the plasmacytoid population. Conclusions: Hashimoto thyroiditis differs both histopathologically and immunohistochemically from thyroid lymphoma. In suspicious cases, immunohistochemistry could be helpful in reaching a definitive diagnosis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=464;epage=471;aulast=AmaniHashimoto thyroiditisimmunohistochemistryprimary thyroid lymphoma |
| spellingShingle | H Kazem Amani Histopathologic and immunohistochemical features of Hashimoto thyroiditis Indian Journal of Pathology and Microbiology Hashimoto thyroiditis immunohistochemistry primary thyroid lymphoma |
| title | Histopathologic and immunohistochemical features of Hashimoto thyroiditis |
| title_full | Histopathologic and immunohistochemical features of Hashimoto thyroiditis |
| title_fullStr | Histopathologic and immunohistochemical features of Hashimoto thyroiditis |
| title_full_unstemmed | Histopathologic and immunohistochemical features of Hashimoto thyroiditis |
| title_short | Histopathologic and immunohistochemical features of Hashimoto thyroiditis |
| title_sort | histopathologic and immunohistochemical features of hashimoto thyroiditis |
| topic | Hashimoto thyroiditis immunohistochemistry primary thyroid lymphoma |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=464;epage=471;aulast=Amani |
| work_keys_str_mv | AT hkazemamani histopathologicandimmunohistochemicalfeaturesofhashimotothyroiditis |