Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer

Caveolin‐1‐driven membrane remodelling regulates hnRNPK‐mediated exosomal microRNA sorting in cancer

Abstract Background Caveolae proteins play diverse roles in cancer development and progression. In prostate cancer, non‐caveolar caveolin‐1 (CAV1) promotes metastasis, while CAVIN1 attenuates CAV1‐induced metastasis. Here, we unveil a novel mechanism linking CAV1 to selective loading of exosomes wit...

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Bibliographic Details
Main Authors: Harley Robinson, Jayde E. Ruelcke, Amanda Lewis, Charles S. Bond, Archa H. Fox, Vandhana Bharti, Shivangi Wani, Nicole Cloonan, Andrew Lai, David Margolin, Li Li, Carlos Salomon, Renée S. Richards, Aine Farrell, Robert A. Gardiner, Robert G. Parton, Alexandre S. Cristino, Michelle M. Hill
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Clinical and Translational Medicine
Subjects:
cancer
cargo
epigenetics
extracellular vesicle
hnRNPK
lipid raft
Online Access:https://doi.org/10.1002/ctm2.381

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