REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study
Abstract Purpose To compare real-life data on delayed intravitreal treatment of diabetic macular edema (DME) patients to early treatment. Methods In this single-centre, retrospective, interventional, comparative study, DME patients were divided into two groups based on when they received treatment:...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-023-00463-y |
| _version_ | 1797853668399120384 |
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| author | Sai Prashanti Chitturi Ramesh Venkatesh Rubble Mangla Yash Parmar Rohini Sangoram Naresh Kumar Yadav Jay Chhablani |
| author_facet | Sai Prashanti Chitturi Ramesh Venkatesh Rubble Mangla Yash Parmar Rohini Sangoram Naresh Kumar Yadav Jay Chhablani |
| author_sort | Sai Prashanti Chitturi |
| collection | DOAJ |
| description | Abstract Purpose To compare real-life data on delayed intravitreal treatment of diabetic macular edema (DME) patients to early treatment. Methods In this single-centre, retrospective, interventional, comparative study, DME patients were divided into two groups based on when they received treatment: Group 1 - received treatment within 24 weeks and Group 2 - at or after 24 weeks from the time of treatment advice. Visual acuity and central subfield thickness (CSFT) changes were compared at various time points. Reasons for delaying treatment were noted. Results The study included 109 (Group 1–94; Group 2–15) eyes. When treatment was advised, demographic profile, diabetes duration, glucose control and VA between two groups were comparable. At this point, CSFT was higher in Group 1 than in Group 2 (p = 0.036). At injection time, Group 2 had better VA and lower CSFT than Group 1 (p < 0.05). Group 2’s VA (53.4 ± 12.67) was significantly lower than Group 1’s (57.38 ± 20.01) after 1-year treatment. At 1-year, CSFT decreased in Group 1 and increased in Group 2. Group 1 had mean improvement of + 7.6 letters and Group 2 had a decline of -6.9 letters. Group 2 required more intravitreal anti-VEGF (median – 3; IQR: 2–4), steroid injections (median – 4; IQR: 2–4) and focal laser sessions (median – 4; IQR: 2–4). Conclusion Late-treated DME eyes needed more injections and focal laser sessions than early treated eyes. Adherence to early treatment of DME in real-life will help prevent long-term vision loss. |
| first_indexed | 2024-04-09T19:54:24Z |
| format | Article |
| id | doaj.art-a1dccb70cef4428cbec7a206c7407831 |
| institution | Directory Open Access Journal |
| issn | 2056-9920 |
| language | English |
| last_indexed | 2024-04-09T19:54:24Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Retina and Vitreous |
| spelling | doaj.art-a1dccb70cef4428cbec7a206c74078312023-04-03T05:35:28ZengBMCInternational Journal of Retina and Vitreous2056-99202023-03-01911810.1186/s40942-023-00463-yREal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT studySai Prashanti Chitturi0Ramesh Venkatesh1Rubble Mangla2Yash Parmar3Rohini Sangoram4Naresh Kumar Yadav5Jay Chhablani6Dept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousDept. of Retina and VitreousMedical Retina and Vitreoretinal Surgery, University of Pittsburgh School of MedicineAbstract Purpose To compare real-life data on delayed intravitreal treatment of diabetic macular edema (DME) patients to early treatment. Methods In this single-centre, retrospective, interventional, comparative study, DME patients were divided into two groups based on when they received treatment: Group 1 - received treatment within 24 weeks and Group 2 - at or after 24 weeks from the time of treatment advice. Visual acuity and central subfield thickness (CSFT) changes were compared at various time points. Reasons for delaying treatment were noted. Results The study included 109 (Group 1–94; Group 2–15) eyes. When treatment was advised, demographic profile, diabetes duration, glucose control and VA between two groups were comparable. At this point, CSFT was higher in Group 1 than in Group 2 (p = 0.036). At injection time, Group 2 had better VA and lower CSFT than Group 1 (p < 0.05). Group 2’s VA (53.4 ± 12.67) was significantly lower than Group 1’s (57.38 ± 20.01) after 1-year treatment. At 1-year, CSFT decreased in Group 1 and increased in Group 2. Group 1 had mean improvement of + 7.6 letters and Group 2 had a decline of -6.9 letters. Group 2 required more intravitreal anti-VEGF (median – 3; IQR: 2–4), steroid injections (median – 4; IQR: 2–4) and focal laser sessions (median – 4; IQR: 2–4). Conclusion Late-treated DME eyes needed more injections and focal laser sessions than early treated eyes. Adherence to early treatment of DME in real-life will help prevent long-term vision loss.https://doi.org/10.1186/s40942-023-00463-yDiabetic macular edemaEarly treatmentDelayed treatmentComplianceOutcomes |
| spellingShingle | Sai Prashanti Chitturi Ramesh Venkatesh Rubble Mangla Yash Parmar Rohini Sangoram Naresh Kumar Yadav Jay Chhablani REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study International Journal of Retina and Vitreous Diabetic macular edema Early treatment Delayed treatment Compliance Outcomes |
| title | REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study |
| title_full | REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study |
| title_fullStr | REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study |
| title_full_unstemmed | REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study |
| title_short | REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema – RETORT study |
| title_sort | real world treatment outcomes after delayed intravitreal therapy in center involving diabetic macular edema retort study |
| topic | Diabetic macular edema Early treatment Delayed treatment Compliance Outcomes |
| url | https://doi.org/10.1186/s40942-023-00463-y |
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